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The Application of Nanoparticles in Biomedicine

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: 20 October 2024 | Viewed by 1181

Special Issue Editor


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Guest Editor
Department of Chemistry, Kyungpook National University, Daegu 41566, Republic of Korea
Interests: nanoparticle; biomedicine; imaging; therapy; nanomaterial
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanoparticles, nanomaterials, nanorods, core–shell nanoparticles, and hybrid nanoparticles have been extensively studied for various biomedical applications. Their applications are diverse such as contrast agents in magnetic resonance imaging (MRI) and X-ray computed tomography (CT), drug delivery, fluorescent imaging, biolabeling, biosensing, etc. Their properties are superior to conventional molecules and chelates. There have been many reports regarding their synthesis, characterization, and applications, demonstrating their unique and advanced properties, which are extremely useful for the diagnosis of diseases.

The aim of this Special Issue is to report a variety of nanoparticles and nanomaterials that can be applied to biomedicine, nanomedicine, and nanobiology. These include the synthesis of nanoparticles and nanomaterials and their characterizations using various techniques, surface modifications, and in vitro and in vivo applications. Surface modification with hydrophilic and biocompatible ligands is essential for their biomedical applications. This Special Issue will cover a variety of nanoparticles and nanomaterials that can be applied to biomedicine, nanomedicine, and nanobiology.

Prof. Dr. Gangho Lee
Guest Editor

Manuscript Submission Information

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Keywords

  • nanoparticle
  • nanomaterial
  • biomedicine
  • imaging
  • therapy
  • contrast agent
  • therapeutic agent

Published Papers (1 paper)

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Research

14 pages, 4582 KiB  
Article
Silver Nanoparticles Encapped by Dihydromyricetin: Optimization of Green Synthesis, Characterization, Toxicity, and Anti-MRSA Infection Activities for Zebrafish (Danio rerio)
by Ling-Xiao Qi, Xue-Ting Wang, Jin-Ping Huang, Ting-Yan Yue, Yun-Shu Lu, Dong-Mei San, Yu-Xun Xu, Ya-Tong Han, Xiang-Yi Guo, Wei-Dong Xie and Yan-Xia Zhou
Int. J. Mol. Sci. 2024, 25(10), 5255; https://doi.org/10.3390/ijms25105255 - 11 May 2024
Viewed by 847
Abstract
To achieve the environmentally friendly and rapid green synthesis of efficient and stable AgNPs for drug-resistant bacterial infection, this study optimized the green synthesis process of silver nanoparticles (AgNPs) using Dihydromyricetin (DMY). Then, we assessed the impact of AgNPs on zebrafish embryo development, [...] Read more.
To achieve the environmentally friendly and rapid green synthesis of efficient and stable AgNPs for drug-resistant bacterial infection, this study optimized the green synthesis process of silver nanoparticles (AgNPs) using Dihydromyricetin (DMY). Then, we assessed the impact of AgNPs on zebrafish embryo development, as well as their therapeutic efficacy on zebrafish infected with Methicillin-resistant Staphylococcus aureus (MRSA). Transmission electron microscopy (TEM) and dynamic light-scattering (DLS) analyses revealed that AgNPs possessed an average size of 23.6 nm, a polymer dispersity index (PDI) of 0.197 ± 0.0196, and a zeta potential of −18.1 ± 1.18 mV. Compared to other published green synthesis products, the optimized DMY-AgNPs exhibited smaller sizes, narrower size distributions, and enhanced stability. Furthermore, the minimum concentration of DMY-AgNPs required to affect zebrafish hatching and survival was determined to be 25.0 μg/mL, indicating the low toxicity of DMY-AgNPs. Following a 5-day feeding regimen with DMY-AgNP-containing food, significant improvements were observed in the recovery of the gills, intestines, and livers in MRSA-infected zebrafish. These results suggested that optimized DMY-AgNPs hold promise for application in aquacultures and offer potential for further clinical use against drug-resistant bacteria. Full article
(This article belongs to the Special Issue The Application of Nanoparticles in Biomedicine)
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