Sperm Oxidative Stress and Male Infertility

Dear Colleagues,

Oxidative stress (OS) in semen is known to be one of the most common and important factors negatively affecting both semen quality and sperm’s ability to fertilize the oocyte. Furthermore, 80% of male idiopathic infertility is associated with the generation of pathological amounts of reactive oxygen species and/or impaired antioxidant capacity, this known as Male Oxidative Stress Infertility (MOSI). Clinically, what is important is that OS in semen can be a causative factor not only in decreased membrane integrity due to the peroxidation of polyunsaturated fatty acid-rich sperm phospholipid membranes but also in sperm DNA fragmentation. Consequently, defective fertilization and embryo development can occur, both in natural and medically assisted conception. Moreover, it should be emphasized that the oxidation of sperm DNA can lead to direct modification of nitrogenous bases that can then be responsible for mutagenic or epigenetic effects likely transmitted to future generations. As such, it is essential to conduct studies focused on the etiology, epidemiology, molecular bases, and clinical consequences and therapies of OS in male infertility. We encourage the submission of original research articles and reviews, especially those that provide results at the molecular level.

Dr. Kamil Gill
Guest Editor

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