Role of Mitochondria in Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 20 May 2025 | Viewed by 1527
Special Issue Editors
Interests: p53; tumor suppressor; phase-separation; droplets; membrane-less organelles; cardiolipin metabolism; mitochondrial quality control; apoptosis; cancer metabolism
Interests: mitochondria; lysosome; drug resistance; cancer stem; glioblastoma; translation; ferroptosis; cancer metabolism
Special Issue Information
Dear Colleagues,
In healthy cells, mitochondria are essential for producing ATP efficiently via respiration, but in pathological situations, they may trigger apoptosis by releasing cytochrome c; thus, they serve critical functions in both cell survival and death. Mitochondria are also central to cellular metabolism. Nearly 100 years ago, Otto Warburg opined, “The mitochondria of cancer cells are abnormal”. He observed that cancer cells predominantly depend on glycolytic energy production, even though they exist in aerobic conditions. Since then, a number of studies have reported mitochondrial dysregulation and dysfunction in cancer cells. However, how and why these abnormal mitochondria contribute to cancer initiation and progression is not entirely clear. This Special Issue seeks to clarify the full picture of mitochondria in cancer. For this purpose, we invite both original and review articles on cancer mitochondria from perspectives of mitochondrial DNA/RNA, proteins, metabolism, apoptosis, oxidative stress, proteostasis, autophagy, lipid, fission and fusion, and droplets. This Special Issue also welcomes both basic and translational research on molecular bases and pathophysiology of cancer mitochondria, and therapeutic and diagnostic applications of dysfunctional mitochondria in cancer.
Prof. Dr. Hirofumi Arakawa
Prof. Dr. Takeshi Uchiumi
Dr. Manabu Futamura
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- metabolism
- apoptosis
- fusion and fission
- mitochondrial DNA
- mitochondrial RNA
- mitochondrial proteins
- mitophagy
- lipid
- cardiolipin
- phase separation
- oxidative phosphorylation
- proteostasis
- mitochondrial quality control
- TFAM
- anti-cancer drug
- imaging
- cancer therapy
- cancer diagnosis
- Warburg effect
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
