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Molecular Advances in Musculoskeletal Disorders

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: closed (20 June 2024) | Viewed by 717

Special Issue Editor


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Guest Editor
Department of Medical and Surgical Specialties and Dentistry, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
Interests: bone; muscle and joint disorders; musculoskeletal rehabilitation; musculoskeletal pain and complex regional pain syndrome

Special Issue Information

Dear Colleagues, 

Musculoskeletal disorders are leading contributors to years lived with disability worldwide, affecting people of all ages. Understanding the pathogenic mechanisms for these conditions is a challenging task for researchers and clinicians that can lead to the development of new strategies to identify different phenotypes, biomarkers for early diagnosis and prognosis as well as to facilitate personalized therapeutic approaches.

The scope of this Special Issue is to gather original articles and comprehensive reviews addressing pathways involved in cartilage, bone, ligament, tendon, muscle injury and repair, as well as their clinical implications in terms of presentation and progression of MSK disorders, diagnostic and prognostic insights, and potential therapeutic strategies for these conditions.

Dr. Antimo Moretti
Guest Editor

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Keywords

  • osteoarthritis
  • osteoporosis
  • sarcopenia
  • tendinopathy
  • musculoskeletal pain

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Published Papers (1 paper)

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Review

17 pages, 1296 KiB  
Review
Role of Magnesium in Skeletal Muscle Health and Neuromuscular Diseases: A Scoping Review
by Sara Liguori, Antimo Moretti, Marco Paoletta, Francesca Gimigliano and Giovanni Iolascon
Int. J. Mol. Sci. 2024, 25(20), 11220; https://doi.org/10.3390/ijms252011220 (registering DOI) - 18 Oct 2024
Viewed by 233
Abstract
Magnesium (Mg) is a vital element for various metabolic and physiological functions in the human body, including its crucial role in skeletal muscle health. Hypomagnesaemia is frequently reported in many muscle diseases, and it also seems to contribute to the pathogenesis of skeletal [...] Read more.
Magnesium (Mg) is a vital element for various metabolic and physiological functions in the human body, including its crucial role in skeletal muscle health. Hypomagnesaemia is frequently reported in many muscle diseases, and it also seems to contribute to the pathogenesis of skeletal muscle impairment in patients with neuromuscular diseases. The aim of this scoping review is to analyze the role of Mg in skeletal muscle, particularly its biological effects on muscle tissue in neuromuscular diseases (NMDs) in terms of biological effects and clinical implications. This scoping review followed the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) guidelines. From the 305 studies identified, 20 studies were included: 4 preclinical and 16 clinical studies. Preclinical research has demonstrated that Mg plays a critical role in modulating pathways affecting skeletal muscle homeostasis and oxidative stress in muscles. Clinical studies have shown that Mg supplementation can improve muscle mass, respiratory muscle strength, and exercise recovery and reduce muscle soreness and inflammation in athletes and patients with various conditions. Despite the significant role of Mg in muscle health, there is a lack of research on Mg supplementation in NMDs. Given the potential similarities in pathogenic mechanisms between NMDs and Mg deficiency, further studies on the effects of Mg supplementation in NMDs are warranted. Overall, maintaining optimal Mg levels through dietary intake or supplementation may have important implications for improving muscle health and function, particularly in conditions associated with muscle weakness and atrophy. Full article
(This article belongs to the Special Issue Molecular Advances in Musculoskeletal Disorders)
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