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Molecular Biology of Gynecological Cancers: From Bench to Bedside

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 9525

Special Issue Editor


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Guest Editor
Department of Obstetrics and Gynecology, University Hospital, LMU, 80539 Munich, Germany
Interests: gynecologic oncology; surgical oncology; clinical trials; personalized medicine

Special Issue Information

Dear Colleagues,

In light of the high prevalence of gynecological cancers and, consequently, the increasing disease burden experienced by women all over the world, there remains a pressing need for further research on novel therapies.

Over the years, there has emerged evidence to suggest that a deep understanding of molecular biology is essential for both the diagnosis and therapy of gynecological cancers, including cervical cancer, ovarian cancer, endometrial cancer, vaginal cancer, and vulvar cancer. In particular, new and reliable prognostic factors, as well as specific targets for new therapeutic approaches, are urgently required. Furthermore, insights into the molecular pathogeneses of these cancers could contribute to efforts to improve our understanding of the malignancies.

This Special Issue of the International Journal of Molecular Sciences on “Molecular Biology of Gynecological Cancers: From Bench to Bedside”, supervised by Dr. Bastian Czogalla (LMU Munich, Germany) and assisted by Dr. Anca Chelariu-Raicu (LMU Munich, Germany), aims at investigating all the molecular aspects of gynecological cancers. We welcome state-of-the-art original research articles, reviews, methods, hypotheses/theories, perspectives, opinions, and commentaries on this important topic. Data on the molecular mechanisms or pathophysiology of the disease are an essential requirement, and papers that contain only clinical trial reports/data will not be considered.

Dr. Bastian Czogalla
Guest Editor

Manuscript Submission Information

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Keywords

  • gynecological cancer
  • cervical cancer
  • ovarian cancer
  • endometrial cancer
  • vaginal cancer
  • vulvar cancer
  • pathways
  • biomarkers
  • diagnostics
  • therapy

Published Papers (1 paper)

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Review

15 pages, 1000 KiB  
Review
The Preventive Role of the Vitamin D Endocrine System in Cervical Cancer
by Euclides Avila, Bryan Javier Noriega-Mejía, Jocelyn González-Macías, Ulises Cortes-Hernández, Janice García-Quiroz, Rocío García-Becerra and Lorenza Díaz
Int. J. Mol. Sci. 2023, 24(10), 8665; https://doi.org/10.3390/ijms24108665 - 12 May 2023
Cited by 6 | Viewed by 9026
Abstract
Vitamin D along with its active metabolite calcitriol and its metabolic and signaling system, known as the vitamin D endocrine system, have been widely recognized as a pivotal regulator of calcium homeostasis in addition to non-calcemic antitumoral effects in a variety of human [...] Read more.
Vitamin D along with its active metabolite calcitriol and its metabolic and signaling system, known as the vitamin D endocrine system, have been widely recognized as a pivotal regulator of calcium homeostasis in addition to non-calcemic antitumoral effects in a variety of human cancers, including cervical cancer. Several studies have found an inverse relationship between the incidence of cervical neoplasia and vitamin D levels. This narrative review updates the current evidence supporting the notion that the vitamin D endocrine system has a preventive role on cervical cancer, mainly in the early phases of the disease, acting at the level of suppressing cell proliferation, promoting apoptosis, modulating inflammatory responses, and probably favoring the clearance of human papillomavirus-dependent cervical lesions. Although an optimal vitamin D status helps in the prevention and regression of low-grade squamous intraepithelial lesions of the cervix, it appears that vitamin D alone or combined with chemotherapeutic agents has little effectivity once advanced cervical cancer is established. These observations suggest that an optimal vitamin D status might exert beneficial actions in the early phases of cervical cancer by preventing its onset and progression. Full article
(This article belongs to the Special Issue Molecular Biology of Gynecological Cancers: From Bench to Bedside)
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