Advanced Molecular Mechanism of Pathogenesis of Osteoarthritis
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 373
Special Issue Editor
Interests: osteoarthritis; cartilage/chondrocyte research
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Recent knowledge of the molecular mechanisms underlying osteoarthritis (OA) progression is accumulating, and deleting a single molecule has been shown to prevent pathogenesis. A senescence-inducible factor in cartilage has been reported; this factor is induced during aging, and its deletion confers resistance in degenerating OA models. In this Special Issue, we present updates on advanced molecular mechanisms of OA pathogenesis, including cell cycle arrest, senescence-promoting molecules, and stem cell senescence.
Dr. Takako Hattori
Guest Editor
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Keywords
- osteoarthritis
- degeneration of cartilage
- mechanical loading
- senescence
- cell cycle
- cellular communication network family member 3 (CCN3)
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