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Advancements in Biocompatible Materials for Dental Applications
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Advancements in Biocompatible Materials for Dental Applications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 3204

Special Issue Editors

Prof. Dr. Youssef Haïkel

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Guest Editor
1. Department of Biomaterials and Bioengineering, INSERM UMR_S 1121, Strasbourg University, 67000 Strasbourg, France
2. Department of Endodontics, Faculty of Dental Medicine, Strasbourg University, 67000 Strasbourg, France
3. Pôle de Médecine et Chirurgie Bucco-Dentaire, Hôpital Civil, Hôpitaux Universitaire de Strasbourg, 67000 Strasbourg, France
Interests: endodontics-cariology; prosthetic therapeutics on implants; biological material–tissue interfaces
Special Issues, Collections and Topics in MDPI journals
Dr. Naji Kharouf

E-Mail Website
Guest Editor
1. Department of Biomaterials and Bioengineering, INSERM UMR_S 1121, Strasbourg University, 67000 Strasbourg, France
2. Department of Endodontics, Faculty of Dental Medicine, Strasbourg University, 67000 Strasbourg, France
Interests: biomaterials; bonding; endodontic; polyphenols; bioceramics; microsurgery
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Davide Mancino

E-Mail
Guest Editor
1. Department of Biomaterials and Bioengineering, INSERM UMR_S 1121, Biomaterials and Bioengineering, 67000 Strasbourg, France
2. Department of Endodontics, Faculty of Dental Medicine, Strasbourg University, 67000 Strasbourg, France
3. Pôle de Médecine et Chirurgie Bucco-Dentaire, Hôpital Civil, Hôpitaux Universitaire de Strasbourg, 67000 Strasbourg, France
Interests: endodontics; root canal treatment; 3D printing; pulp regeneration; tooth anatomy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We welcome your submissions of original research articles and review manuscripts that address all aspects of the modification, development, invention, and application of dental biomaterials, with particular focus on the molecular aspects of dental biomaterials research. This Special Issue covers all aspects of the application of dental materials in various fields, such as endodontic treatment, conservative procedure, diagnostic steps, prosthetic restoration, pediatric dentistry, orthodontics, implantology, parodontology, prevention, and surgical process. We seek to combine molecular research and practical dental applications, shedding light on innovative developments in biocompatible materials that play crucial roles in modern dentistry. The purpose of dental biomaterials is to restore teeth and infected tissues, including areas affected by caries or dental anomalies/diseases. This Special Issue, which is titled “Advancements in Biocompatible Materials for Dental Applications”, will showcase cutting-edge research exploring the molecular intricacies of these materials, their interactions with oral tissues, and their impacts on dental health.

We invite you to join us in shaping the future of dental materials by sharing your latest research findings and experimental breakthroughs.

Prof. Dr. Youssef Haïkel
Dr. Naji Kharouf
Dr. Davide Mancino
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactivity
  • biocompatibility
  • endodontic treatment
  • restorative material
  • esthetic procedure
  • microsurgical steps
  • prosthetic—direct and indirect restorations
  • digital and printing procedures

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Published Papers (2 papers)

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Research

13 pages, 6940 KiB  
Article
Graphene Far-Infrared Irradiation Can Effectively Relieve the Blood Pressure Level of Rat Untr-HT in Primary Hypertension
by Guanjie Lu, Haotong Guo, Yi Zhang, Meng Zhang, Tao Zhang, Ge Hu and Qian Zhang
Int. J. Mol. Sci. 2024, 25(12), 6675; https://doi.org/10.3390/ijms25126675 - 18 Jun 2024
Viewed by 941
Abstract
Graphene, when electrified, generates far-infrared radiation within the wavelength range of 4 μm to 14 μm. This range closely aligns with the far-infrared band (3 μm to 15 μm), which produces unique physiological effects. Contraction and relaxation of vascular smooth muscle play a [...] Read more.
Graphene, when electrified, generates far-infrared radiation within the wavelength range of 4 μm to 14 μm. This range closely aligns with the far-infrared band (3 μm to 15 μm), which produces unique physiological effects. Contraction and relaxation of vascular smooth muscle play a significant role in primary hypertension, involving the nitric oxide-soluble guanylate cyclase–cyclic guanosine monophosphate pathway and the renin–angiotensin–aldosterone system. This study utilized spontaneously hypertensive rats (SHRs) as an untr-HT to investigate the impact of far-infrared radiation at specific wavelengths generated by electrified graphene on vascular smooth muscle and blood pressure. After 7 weeks, the blood pressure of the untr-HT group rats decreased significantly with a notable reduction in the number of vascular wall cells and the thickness of the vascular wall, as well as a decreased ratio of vessel wall thickness to lumen diameter. Additionally, blood flow perfusion significantly increased, and the expression of F-actin in vascular smooth muscle myosin decreased significantly. Serum levels of angiotensin II (Ang-II) and endothelin 1 (ET-1) were significantly reduced, while nitric oxide synthase (eNOS) expression increased significantly. At the protein level, eNOS expression decreased significantly, while α-SMA expression increased significantly in aortic tissue. At the gene level, expressions of eNOS and α-SMA in aortic tissue significantly increased. Furthermore, the content of nitric oxide (NO) in the SHR’s aortic tissue increased significantly. These findings confirm that graphene far-infrared radiation enhances microcirculation, regulates cytokines affecting vascular smooth muscle contraction, and modifies vascular morphology and smooth muscle phenotype, offering relief for primary hypertension. Full article
(This article belongs to the Special Issue Advancements in Biocompatible Materials for Dental Applications)
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22 pages, 41854 KiB  
Article
Injectable Xenogeneic Dental Pulp Decellularized Extracellular Matrix Hydrogel Promotes Functional Dental Pulp Regeneration
by Shengmeng Yuan, Xueting Yang, Xiuting Wang, Jinlong Chen, Weidong Tian and Bo Yang
Int. J. Mol. Sci. 2023, 24(24), 17483; https://doi.org/10.3390/ijms242417483 - 14 Dec 2023
Cited by 4 | Viewed by 1683
Abstract
The present challenge in dental pulp tissue engineering scaffold materials lies in the development of tissue-specific scaffolds that are conducive to an optimal regenerative microenvironment and capable of accommodating intricate root canal systems. This study utilized porcine dental pulp to derive the decellularized [...] Read more.
The present challenge in dental pulp tissue engineering scaffold materials lies in the development of tissue-specific scaffolds that are conducive to an optimal regenerative microenvironment and capable of accommodating intricate root canal systems. This study utilized porcine dental pulp to derive the decellularized extracellular matrix (dECM) via appropriate decellularization protocols. The resultant dECM was dissolved in an acid pepsin solution to form dECM hydrogels. The analysis encompassed evaluating the microstructure and rheological properties of dECM hydrogels and evaluated their biological properties, including in vitro cell viability, proliferation, migration, tube formation, odontogenic, and neurogenic differentiation. Gelatin methacrylate (GelMA) hydrogel served as the control. Subsequently, hydrogels were injected into treated dentin matrix tubes and transplanted subcutaneously into nude mice to regenerate dental pulp tissue in vivo. The results showed that dECM hydrogels exhibited exceptional injectability and responsiveness to physiological temperature. It supported the survival, odontogenic, and neurogenic differentiation of dental pulp stem cells in a 3D culture setting. Moreover, it exhibited a superior ability to promote cell migration and angiogenesis compared to GelMA hydrogel in vitro. Additionally, the dECM hydrogel demonstrated the capability to regenerate pulp-like tissue with abundant blood vessels and a fully formed odontoblast-like cell layer in vivo. These findings highlight the potential of porcine dental pulp dECM hydrogel as a specialized scaffold material for dental pulp regeneration. Full article
(This article belongs to the Special Issue Advancements in Biocompatible Materials for Dental Applications)
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