International Journal of Molecular Sciences

Journal Browser

► Journal Browser

Special Issue Editors

Prof. Dr. Youssef Haïkel

E-Mail Website
Guest Editor

1. Department of Biomaterials and Bioengineering, INSERM UMR_S 1121, Strasbourg University, 67000 Strasbourg, France
2. Department of Endodontics, Faculty of Dental Medicine, Strasbourg University, 67000 Strasbourg, France
3. Pôle de Médecine et Chirurgie Bucco-Dentaire, Hôpital Civil, Hôpitaux Universitaire de Strasbourg, 67000 Strasbourg, France
Interests: endodontics-cariology; prosthetic therapeutics on implants; biological material–tissue interfaces
Special Issues, Collections and Topics in MDPI journals

Dr. Naji Kharouf

E-Mail Website
Guest Editor

1. Department of Biomaterials and Bioengineering, INSERM UMR_S 1121, Strasbourg University, 67000 Strasbourg, France
2. Department of Endodontics, Faculty of Dental Medicine, Strasbourg University, 67000 Strasbourg, France
Interests: biomaterials; bonding; endodontic; polyphenols; bioceramics; microsurgery
Special Issues, Collections and Topics in MDPI journals

Prof. Dr. Davide Mancino

E-Mail
Guest Editor

1. Department of Biomaterials and Bioengineering, INSERM UMR_S 1121, Biomaterials and Bioengineering, 67000 Strasbourg, France
2. Department of Endodontics, Faculty of Dental Medicine, Strasbourg University, 67000 Strasbourg, France
3. Pôle de Médecine et Chirurgie Bucco-Dentaire, Hôpital Civil, Hôpitaux Universitaire de Strasbourg, 67000 Strasbourg, France
Interests: endodontics; root canal treatment; 3D printing; pulp regeneration; tooth anatomy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We welcome your submissions of original research articles and review manuscripts that address all aspects of the modification, development, invention, and application of dental biomaterials, with particular focus on the molecular aspects of dental biomaterials research. This Special Issue covers all aspects of the application of dental materials in various fields, such as endodontic treatment, conservative procedure, diagnostic steps, prosthetic restoration, pediatric dentistry, orthodontics, implantology, parodontology, prevention, and surgical process. We seek to combine molecular research and practical dental applications, shedding light on innovative developments in biocompatible materials that play crucial roles in modern dentistry. The purpose of dental biomaterials is to restore teeth and infected tissues, including areas affected by caries or dental anomalies/diseases. This Special Issue, which is titled “Advancements in Biocompatible Materials for Dental Applications”, will showcase cutting-edge research exploring the molecular intricacies of these materials, their interactions with oral tissues, and their impacts on dental health.

We invite you to join us in shaping the future of dental materials by sharing your latest research findings and experimental breakthroughs.

Prof. Dr. Youssef Haïkel
Dr. Naji Kharouf
Dr. Davide Mancino
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

bioactivity
biocompatibility
endodontic treatment
restorative material
esthetic procedure
microsurgical steps
prosthetic—direct and indirect restorations
digital and printing procedures

Published Papers (1 paper)

Research

22 pages, 41854 KiB

Open AccessArticle

Injectable Xenogeneic Dental Pulp Decellularized Extracellular Matrix Hydrogel Promotes Functional Dental Pulp Regeneration

by Shengmeng Yuan, Xueting Yang, Xiuting Wang, Jinlong Chen, Weidong Tian and Bo Yang

Int. J. Mol. Sci. 2023, 24(24), 17483; https://doi.org/10.3390/ijms242417483 - 14 Dec 2023

Cited by 1 | Viewed by 1024

Abstract

The present challenge in dental pulp tissue engineering scaffold materials lies in the development of tissue-specific scaffolds that are conducive to an optimal regenerative microenvironment and capable of accommodating intricate root canal systems. This study utilized porcine dental pulp to derive the decellularized extracellular matrix (dECM) via appropriate decellularization protocols. The resultant dECM was dissolved in an acid pepsin solution to form dECM hydrogels. The analysis encompassed evaluating the microstructure and rheological properties of dECM hydrogels and evaluated their biological properties, including in vitro cell viability, proliferation, migration, tube formation, odontogenic, and neurogenic differentiation. Gelatin methacrylate (GelMA) hydrogel served as the control. Subsequently, hydrogels were injected into treated dentin matrix tubes and transplanted subcutaneously into nude mice to regenerate dental pulp tissue in vivo. The results showed that dECM hydrogels exhibited exceptional injectability and responsiveness to physiological temperature. It supported the survival, odontogenic, and neurogenic differentiation of dental pulp stem cells in a 3D culture setting. Moreover, it exhibited a superior ability to promote cell migration and angiogenesis compared to GelMA hydrogel in vitro. Additionally, the dECM hydrogel demonstrated the capability to regenerate pulp-like tissue with abundant blood vessels and a fully formed odontoblast-like cell layer in vivo. These findings highlight the potential of porcine dental pulp dECM hydrogel as a specialized scaffold material for dental pulp regeneration. Full article

(This article belongs to the Special Issue Advancements in Biocompatible Materials for Dental Applications)

► Show Figures

Graphical abstract

Journal Menu

Journal Browser

Advancements in Biocompatible Materials for Dental Applications

Share This Special Issue

Special Issue Editors

Special Issue Information

Keywords

Published Papers (1 paper)

Research

Further Information

Guidelines

MDPI Initiatives

Follow MDPI