Genetics of Disease and Health Outcomes under the Influence of Environmental Factors
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 October 2024 | Viewed by 58
Special Issue Editor
Interests: environmental effects of condition; ecophysiology; epigenetic impact; environmental biogeochemistry; genetic polymorphisms
Special Issue Information
Dear Colleagues,
According to Tim Spector, Professor of genetic epidemiology, Kings College, London, one of the pioneers of epigenetics, who conducts research into the influence of the environment on DNA, there was a real revolution in genetics: long-standing scientific dogmas said that once we inherit genes, the environment would not change them and we would stay with them until we die. It has recently become known that genes can change as a result of lifestyles, and that these changes can persist and be passed on to future generations. Thanks to recently explored epigenetic processes, genes are turned on and off, so that even twins with identical genotypes can clearly differ from each other.
Environmental external and internal stressors can change epigenetic patterns through DNA methylation, thereby affecting gene activation and cell phenotype. For a long time, DNA methylation analysis was hampered by a lack of a sensitive and high-throughput method. After ions enter the body, a long sequence of chemical reactions begins, causing cell, tissue, or whole-organ dysfunction. Then, external signs of malfunction appear.
Given the increasing threats and impacts of environmental factors (WHO) on human health and disease, it is very important to study the mechanisms and possible preventive measures. Hence this Special Issue aims to comprehensively show the inter-relationships between environmental factors and the reactions of an organism (individual) at the organ, cellular, and subcellular levels. Our goal is to analyze the importance of ecophysiological mechanisms, processes, reactions, and phenomena, as well as their importance in medicine, physiology, and environmental activity in order to prevent the development of environmental abnormalities related to the body’s condition and health. We welcome both full-length and short research original papers, hypothesis papers, reviews, mini reviews etc.
Dr. Piotr Kamiński
Guest Editor
Manuscript Submission Information
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Keywords
- environmental factors
- ecophysiological determinations
- genetic predispositions
- gene expression
- defensive responses
- pathophysiological abnormalities
- lifestyle diseases
- polymorphisms
