Neuropathological Features of Aging and Neurodegenerative Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 31 July 2024 | Viewed by 1382
Special Issue Editor
Special Issue Information
Dear Colleagues,
In recent years, the relationship between abnormal protein accumulation in neurons and aging has garnerd significant attention, particularly in the context of neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease. Understanding the changes in the brain and the aging process of neural tissues is a crucial step towards preventing and treating neurodegenerative disease, and Alzheimer’s disease (AD) and Parkinson’s disease (PD) constitute representative examples. Notably, the FDA’s approval of antibody therapy targeting amyloid beta in AD has sparked considerable interest. This milestone holds great significance in AD, a disease characterized by the presence of two types of abnormal protein accumulation: tau and amyloid. While antibody therapies for PD, primarily targeting alpha-synuclein, were anticipated, unfortunately, they were all prematurely halted during their clinical trials.
This Special Issue aims to focus on the association between aging and neurodegenerative disease while highlighting neuropathological features and presenting the latest research findings in this field. By comprehending the changes in the brain during aging, we will delve into the neuropathological characteristics of major neurodegenerative disease, such as AD, PD, PSP, and CBD. Moreover, we will provide an overview of the recent advancements in research related to abnormal proteins implicated in neurodegenerative diseases, including tau, amyloid beta, and alpha-synuclein. The potential for early diagnosis and treatment strategies based on neuropathological features will also be addressed. Through this refined collection of articles, we aim to shed light on the intricate connection between aging and neurodegenerative diseases, offering valuable findings for researchers, clinicians, and healthcare professionals, and fostering new perspectives in the understanding and management of neurodegenerative disorders.
Dr. Renpei Sengoku
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- neuropathology
- aging
- Alzheimer’s disease
- Parkinson’s disease
- Parkinsonism
- progressive supranuclear palsy
- cortcobasal degeneration
Planned Papers
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
In recent years, the relationship between abnormal protein accumulation in neurons and aging has garnerd significant attention, particularly in the context of neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease. Understanding the changes in the brain and the aging process of neural tissues is a crucial step towards preventing and treating neurodegenerative disease, and Alzheimer’s disease (AD) and Parkinson’s disease (PD) constitute representative examples. Notably, the FDA’s approval of antibody therapy targeting amyloid beta in AD has sparked considerable interest. This milestone holds great significance in AD.
This Special Issue aims to focus on the association between aging and neurodegenerative disease while highlighting neuropathological features and presenting the latest research findings in this field. By comprehending the changes in the brain during aging, we will delve into the neuropathological characteristics of major neurodegenerative disease. Moreover, we will provide an overview of the recent advancements in research related to abnormal proteins implicated in neurodegenerative diseases, including tau, amyloid beta, and alpha-synuclein.
