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Molecular Imaging for Cancer Theranostics

Special Issue Editors


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Guest Editor
Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02119, USA
Interests: molecular imaging; bioimaging; nanomedicine; biodistribution
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02119, USA
Interests: molecular design; multimodal imaging; theranostic imaging; nanomedicine; structure-inherent targeting

Special Issue Information

Dear Colleagues,

This Special Issue focuses on recent advancements in molecular imaging and theranostics in cancer research. With the advencement of precision medicine, molecular imaging techniques have enabled cancer visualization at cellular and molecular levels, allowing for earlier and more accurate diagnosis. Additionally, theranostic approaches combine diagnostic and therapeutic strategies to target cancer more effectively, opening new avenues for personalized treatment. Contributions addressing novel imaging agents, molecular probes, multimodal imaging, and targeted therapy approaches are particularly welcome.

Dr. Hak Soo Choi
Dr. Kai Bao
Guest Editors

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Keywords

  • molecular imaging
  • cancer theranostics
  • precision medicine
  • targeted therapy
  • diagnostic imaging
  • theranostic agents
  • multimodal imaging
  • molecular probes

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Published Papers (1 paper)

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Research

14 pages, 3752 KiB  
Article
Indocyanine Blue (ICB) as a Functional Alternative to Indocyanine Green (ICG) for Enhanced 700 nm NIR Imaging
by Atsushi Yamashita, Paul Jang, Kai Bao, Satoshi Kashiwagi, John V. Frangioni and Hak Soo Choi
Int. J. Mol. Sci. 2024, 25(24), 13547; https://doi.org/10.3390/ijms252413547 - 18 Dec 2024
Viewed by 1038
Abstract
Despite significant advancements in bioimaging technology, only a limited number of fluorophores are currently approved for clinical applications. Indocyanine green (ICG) is the first FDA-approved near-infrared (NIR) fluorophore and has significantly advanced clinical interventions over the past three decades. However, its single-channel imaging [...] Read more.
Despite significant advancements in bioimaging technology, only a limited number of fluorophores are currently approved for clinical applications. Indocyanine green (ICG) is the first FDA-approved near-infrared (NIR) fluorophore and has significantly advanced clinical interventions over the past three decades. However, its single-channel imaging at 800 nm emission is often insufficient for capturing comprehensive diagnostic information during surgery. In this study, we evaluate indocyanine blue (ICB), an ICG analog with a shorter polymethine bridge, as a promising candidate for multi-channel NIR imaging. ICB demonstrated peak absorption and emission approximately 100 nm shorter than ICG in aqueous solutions, placing it within the 700 nm range of the NIR window. Furthermore, ICB exhibited favorable solubility and optical properties in aqueous environments, supporting its potential for in vivo imaging applications. Notably, ICB shows rapid systemic clearance, likely due to its lower molecular weight, which facilitates clear visualization in angiography, cholangiography, and lymph node mapping with minimal background interference. Additionally, dual-channel imaging of tumors and lymph nodes was achieved using a tumor-targeting fluorophore in conjunction with ICB, illustrating the potential for enhanced intraoperative guidance. ICB emitting at 700 nm, therefore, can be useful in NIR imaging, broadening the possibilities for improved diagnostic accuracy and therapeutic outcomes in clinical settings. Full article
(This article belongs to the Special Issue Molecular Imaging for Cancer Theranostics)
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