Pain: From Bench to Bedside
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 February 2026 | Viewed by 121
Special Issue Editors
Interests: regenerative medicine; growth factors; gene therapy; exosomes; extracellular vesicles; proteomics; genomics; CRISPR; stem cells
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue, “Pain: From Bench to Bedsides”, highlights advances in the mechanistic understanding of pain and the translation into novel therapeutic treatments. Despite significant unmet clinical needs, recent scientific discoveries have identified new targets across ion channels, neuroimmune pathways, and receptor systems, enabling the development of non-opioid analgesics and biologics. This issue will feature research on emerging therapies targeting pathways such as TRP channels, NaV channels, CGRP, glial modulation, and ascending and descending modulating pain pathways, among others. Contributions leveraging transcriptomics, proteomics, neuromodulation, and imaging to elucidate pain pathophysiology are encouraged. Additionally, the integration of machine learning into drug discovery is accelerating the identification of candidate molecules and optimizing pharmacological profiles. Submissions exploring machine learning-driven target prediction, compound screening, and structure-activity modeling are particularly welcome. By bridging molecular insights with therapeutic development, this issue aims to provide a comprehensive view of current strategies advancing the treatment of acute and chronic pain conditions across clinical and translational domains.
Dr. Christopher Robinson
Dr. Robert J. Yong
Guest Editors
Manuscript Submission Information
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Keywords
- CGRP pathway
- chronic pain
- drug discovery
- ion channels
- machine learning
- molecular targets
- neuroimmune signaling
- non-opioid analgesics
- translational pain research
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