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Regenerative Medicine: Molecular Mechanisms Driving Tissue Regeneration and Repair

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 November 2025 | Viewed by 530

Special Issue Editors


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Guest Editor
Department of Anesthesiology, Perioperative, and Pain Medicine, Harvard Medical School, Boston, MA 02115, USA
Interests: regenerative medicine; growth factors; gene therapy; exosomes; extracellular vesicles; proteomics; genomics; CRISPR; stem cells
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Division of Pain Medicine, Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Interests: regenerative medicine; gene therapy; stem cells; platelet-rich plasma
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The restoration of damaged or diseased tissues through regenerative medicine holds significant potential across a wide range of clinical applications. While major strides have been made in cell-based therapies, biomaterials, and tissue engineering, a detailed understanding of the molecular mechanisms that orchestrate tissue regeneration and repair remains critical to advancing safe and effective therapies. This Special Issue of the International Journal of Molecular Sciences invites original research articles and reviews focused on elucidating the molecular and cellular pathways that underline regenerative processes in mammalian systems. Topics of interest include but are not limited to the following: stem cells and signaling, immune modulation in repair, extracellular matrix remodeling, mechanotransduction, epigenetic reprogramming, and the role of growth factors, gene regulation, gene editing, or extracellular vesicles in regeneration.

By bringing together high-impact research at the interface of molecular biology and regenerative medicine, this Special Issue aims to foster deeper mechanistic insights that will inform next-generation therapeutic strategies for tissue restoration and functional recovery.

Dr. Christopher Robinson
Dr. Paul Jordan Christo
Guest Editors

Manuscript Submission Information

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Keywords

  • stem cell
  • cell signaling
  • immune modulation
  • extracellular matrix
  • remodeling
  • gene regulation
  • gene editing
  • growth factors
  • extracellular vesicles
  • small molecules

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Published Papers (1 paper)

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Review

21 pages, 1744 KB  
Review
Fibroblast–Myofibroblast Transition in Osteoarthritis Progression: Current Insights
by Ruixin Peng, Qiyuan Lin, Zhen Yang, Hui Li, Jiao Jiao Li and Dan Xing
Int. J. Mol. Sci. 2025, 26(16), 7881; https://doi.org/10.3390/ijms26167881 - 15 Aug 2025
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Abstract
Osteoarthritis (OA) is a multifactorial joint disease traditionally characterized by cartilage degradation, while growing evidence underscores the critical role of synovial fibrosis in driving disease progression. The synovium exhibits pathological remodeling in OA, primarily due to the phenotypic transition of fibroblast-like synoviocytes (FLSs) [...] Read more.
Osteoarthritis (OA) is a multifactorial joint disease traditionally characterized by cartilage degradation, while growing evidence underscores the critical role of synovial fibrosis in driving disease progression. The synovium exhibits pathological remodeling in OA, primarily due to the phenotypic transition of fibroblast-like synoviocytes (FLSs) into myofibroblasts. This fibroblast–myofibroblast transition (FMT) results in excessive deposition of extracellular matrix (ECM) and increased tissue stiffness and contractility, collectively contributing to chronic inflammation and fibrotic stiffening of the joint capsule. These fibrotic changes not only impair synovial function but also exacerbate cartilage degeneration, nociceptive sensitization, and joint dysfunction, thereby amplifying OA severity. Focusing on the frequently overlooked role of the FMT of synovial fibroblasts in OA, this review introduces the biological characteristics of FLSs and myofibroblasts and systematically examines the key molecular pathways implicated in OA-related FMT, including TGF-β, Wnt/β-catenin, YAP/TAZ, and inflammatory signaling cascades. It also discusses emerging therapeutic strategies targeting synovial fibrosis and FMT and considers their implications for the clinical management of OA. By highlighting recent advances and unresolved challenges, this review provides critical insights into the fibroblast–myofibroblast axis as a central contributor to OA progression and a promising therapeutic target for modifying disease trajectory. Full article
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