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Bioactive Food Compounds in the Prevention and Treatment of Non-Communicable Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 20 October 2025 | Viewed by 1571

Special Issue Editor


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Guest Editor
Department of Human Nutrition and Dietetics, University of Agriculture in Krakow, Krakow, Poland
Interests: bioactive food compounds; human nutrition; non-communicable diseases

Special Issue Information

Dear Colleagues,

Bioactive, non-nutrient food compounds have been studied by scientists around the world for many years, and many have been shown to improve human health. These include dietary fiber, polyphenols, and sulfur compounds, among others. Polyphenols and sulfur compounds have strong antioxidant properties, which is why they reduce oxidative stress and, subsequently, inflammation, and can inhibit tissue cell damage and the development of chronic non-communicable diseases. The mechanism of action of bioactive compounds is often not fully understood because they act in many ways; it is important to understand how they work at the cellular level as well as the recommended daily intake. These findings may help in the prevention and treatment of non-communicable diseases.

Prof. Aneta Kopeć
Guest Editor

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Keywords

  • bioactive compounds
  • dietary fiber
  • polyphenols
  • sulfur compounds
  • antioxidant
  • reduce oxidative stress
  • inflammation
  • non-communicable diseases

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Published Papers (1 paper)

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Research

23 pages, 2274 KiB  
Article
The Combination of Resveratrol and Conjugated Linoleic Acid Dienes Enhances the Individual Effects of These Molecules on De Novo Fatty Acid Biosynthesis in 3T3-L1 Adipocytes
by Jarosław Oczkowicz, Ewelina Piasna-Słupecka, Mariola Drozdowska, Aneta Koronowicz and Aneta Kopeć
Int. J. Mol. Sci. 2024, 25(24), 13429; https://doi.org/10.3390/ijms252413429 - 14 Dec 2024
Viewed by 1255
Abstract
Consuming food containing ingredients with a documented impact on lipid metabolism can help fight overweight and obesity. The simplest way to reduce the level of fatty acids is to block their synthesis or increase the rate of their degradation. This study aimed to [...] Read more.
Consuming food containing ingredients with a documented impact on lipid metabolism can help fight overweight and obesity. The simplest way to reduce the level of fatty acids is to block their synthesis or increase the rate of their degradation. This study aimed to determine the effect of resveratrol, cis-9, trans-11 conjugated linoleic acid (CLA), trans-10, cis-12 CLA, and various variants of their combinations on de novo fatty acid biosynthesis in 3T3-L1 adipocytes. The influence of the above-mentioned bioactive substances on cells grown under standard conditions and after induction of oxidative stress was measured. The effect of the tested compounds on the expression of selected genes related to the de novo fatty acid biosynthesis process (Fasn, Acc1, Acly, Prkaa1, Prkaa2, Prkaca, Srebp1) was evaluated. As part of the conducted experiments, how the level of the corresponding mRNA translates into the content of selected proteins (acetyl-CoA carboxylase 1 (ACC) and fatty acid synthase (FASN) was studied. It was found that the inhibition of fatty acid biosynthesis processes was stronger in the case of the combination of the tested CLA isomers (cis-9, trans-11 CLA, trans-10, cis-12 CLA) with resveratrol than in cases of their individual action. Full article
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