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Newer Pharmacological Treatment Concepts for Patients with Acute Coronary Syndrome

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: 30 March 2025 | Viewed by 975

Special Issue Editor


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Guest Editor
Outpatient Department of Cardiometabolic Medicine, Second Department of Cardiology, Aristotle University of Thessaloniki, General Hospital “Hippokration”, 57001 Thessaloniki, Greece
Interests: type 2 diabetes mellitus; diabetic complications; cardiovascular disease; heart failure; chronic kidney disease
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Special Issue Information

Dear Colleagues,

Despite advances in the interventional management of acute coronary syndrome (ACS), pharmacological treatment options have remained relatively unchanged. As a result, this patient population continues to experience high rates of mortality and morbidity, posing a significant burden on healthcare systems. This Special Issue aims to explore the latest developments in drug therapies for ACS, focusing on innovative treatment strategies, novel drug classes, and personalized medicine approaches. Given the rapid evolution of cardiovascular pharmacotherapy, there is an increasing need for in-depth insights into the efficacy, safety, and clinical application of new therapeutic agents, ranging from antiplatelet and anticoagulant drugs to lipid-lowering therapies, among others. By highlighting emerging treatment options, assessing comparative effectiveness, and examining the integration of novel agents into current clinical practice, this Special Issue aims to advance our understanding of modern pharmacological interventions that have the potential to improve patient outcomes and reduce the burden of ACS.

The investigations we will focus our attention on are fundamentally cellular/molecular studies; papers that only contain clinical trials/data will not be accepted.

This Special Issue is supervised by Dr. Dimitrios Patoulias and assisted by Dr. Paschalis Karakasis(Aristotle University of Thessaloniki).

Dr. Dimitrios Patoulias
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • acute coronary syndrome (ACS)
  • molecular studies
  • antiplatelet
  • anticoagulant drugs
  • lipid-lowering therapies

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Published Papers (1 paper)

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Research

20 pages, 11711 KiB  
Article
CITE-Seq Analysis Reveals a Differential Natural Killer Cell SPON2 Expression in Cardiovascular Disease Patients Impacted by Human-Cytomegalovirus Serostatus and Diabetes
by Sujit Silas Armstrong, Daniel G. Chen, Sunil Kumar, James R. Heath, Matthew J. Feinstein, John R. Greenland, Daniel R. Calabrese, Lewis L. Lanier, Klaus Ley and Avishai Shemesh
Int. J. Mol. Sci. 2025, 26(3), 1369; https://doi.org/10.3390/ijms26031369 - 6 Feb 2025
Viewed by 771
Abstract
Coronary artery disease (CAD) is linked to atherosclerosis plaque formation. In pro-inflammatory conditions, human Natural Killer (NK) cell frequencies in blood or plaque decrease; however, NK cells are underexplored in CAD pathogenesis, inflammatory mechanisms, and CAD comorbidities, such as human cytomegalovirus (HCMV) infection [...] Read more.
Coronary artery disease (CAD) is linked to atherosclerosis plaque formation. In pro-inflammatory conditions, human Natural Killer (NK) cell frequencies in blood or plaque decrease; however, NK cells are underexplored in CAD pathogenesis, inflammatory mechanisms, and CAD comorbidities, such as human cytomegalovirus (HCMV) infection and diabetes. Analysis of PBMC CITE-seq data from sixty-one CAD patients revealed higher blood NK cell SPON2 expression in CAD patients with higher stenosis severity. Conversely, NK cell SPON2 expression was lower in pro-inflammatory atherosclerosis plaque tissue with an enriched adaptive NK cell gene signature. In CAD patients with higher stenosis severity, peripheral blood NK cell SPON2 expression was lower in patients with high HCMV-induced adaptive NK cell frequencies and corresponded to lower PBMC TGFβ transcript expression with dependency on diabetes status. These results suggest that high NK cell SPON2 expression is linked to atherosclerosis pro-homeostatic status and may have diagnostic and prognostic implications in cardiovascular disease. Full article
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