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Nanomaterials/Nanocarriers for Drug Delivery for Application in Cancer Therapy

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: closed (30 January 2024) | Viewed by 2191

Special Issue Editors


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Guest Editor
1. CEB—Centre of Biological Engineering, University of Minho, 4710-057 Braga, Portugal
2. LABBELS-Associate Laboratory, 4710-057 Braga, Portugal
Interests: biosurfactants; bioactive molecules; adhesion and biofilms; synthetic biology; industrial biotechnology; bioprocess development; functional food and biomarkers
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. CEB—Centre of Biological Engineering, University of Minho, 4710-057 Braga, Portugal
2. LABBELS-Associate Laboratory, 4710-057 Braga, Portugal
Interests: biosurfactants; synthetic biology; industrial biotechnology; bioprocess development; biomarkers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Conventional chemotherapy is widely used to eradicate tumor cells through several different mechanisms, aiming to kill growing cells, which includes both tumor and normal cells. This causes serious side effects such as bone marrow suppression, gastrointestinal perturbations, and hair loss. Another main hindrance in tumor management is the development of drug resistance. As cancer remains the second leading cause of death worldwide, more studies and research are needed to overcome the abovementioned limitations of chemotherapy.

In recent years, unprecedented novel nanocarriers/nanostructures have emerged and been exploited with the purpose of delivering drugs at the desired sites with reduced side effects and with a potential pharmacological response. These nanocarrier-based drug delivery systems are being used against several types of malignant tumors. Moreover, different types of nanocarriers have been successfully adopted in various nanomedicines, usually designed according to the pathophysiology of the tumors.

This Special Issue of the International Journal of Molecular Sciences, entitled “Nanomaterials/Nanocarriers for Drug Delivery for Application in Cancer Therapy”, welcomes the submission of original articles or reviews on the use of nanoparticles to precisely deliver drugs during cancer treatment, addressing the potential and limitations of such systems, highlighting novel treatment trends, and assessing mechanisms of action. Topics of interest for this Special Issue include, but are not limited to, the following:

  • Synthesis strategies and methodologies of novel nanomaterials;
  • Characterization of the properties of novel nanocarriers;
  • Studies regarding drug loading and release from nanocarriers;
  • Mechanisms underlying the nanocarriers in vivo;
  • Targeted/modified nanocarriers as delivery vehicles.

Dr. Lígia R. Rodrigues
Dr. Debora Ferreira
Guest Editors

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Published Papers (1 paper)

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Research

15 pages, 1751 KiB  
Article
Preclinical Assessment of ADAM9-Responsive Mesoporous Silica Nanoparticles for the Treatment of Pancreatic Cancer
by Etienne J. Slapak, Mouad el Mandili, Marieke S. Ten Brink, Alexander Kros, Maarten F. Bijlsma and C. Arnold Spek
Int. J. Mol. Sci. 2023, 24(13), 10704; https://doi.org/10.3390/ijms241310704 - 27 Jun 2023
Cited by 1 | Viewed by 1722
Abstract
Pancreatic adenocarcinoma (PDAC) remains largely refractory to chemotherapeutic treatment regimens and, consequently, has the worst survival rate of all cancers. The low efficacy of current treatments results largely from toxicity-dependent dose limitations and premature cessation of therapy. Recently, targeted delivery approaches that may [...] Read more.
Pancreatic adenocarcinoma (PDAC) remains largely refractory to chemotherapeutic treatment regimens and, consequently, has the worst survival rate of all cancers. The low efficacy of current treatments results largely from toxicity-dependent dose limitations and premature cessation of therapy. Recently, targeted delivery approaches that may reduce off-target toxicities have been developed. In this paper, we present a preclinical evaluation of a PDAC-specific drug delivery system based on mesoporous silica nanoparticles (MSNs) functionalized with a protease linker that is specifically cleaved by PDAC cells. Our previous work demonstrated that ADAM9 is a PDAC-enriched protease and that paclitaxel-loaded ADAM9-responsive MSNs effectively kill PDAC cells in vitro. Here, we show that paclitaxel-loaded ADAM9-MSNs result in off-target cytotoxicity in clinically relevant models, which spurred the development of optimized ADAM9-responsive MSNs (OPT-MSNs). We found that these OPT-MSNs still efficiently kill PDAC cells but, as opposed to free paclitaxel, do not induce death in neuronal or bone marrow cells. In line with these in vitro data, paclitaxel-loaded OPT-MSNs showed reduced organ damage and leukopenia in a preclinical PDAC xenograft model. However, no antitumor response was observed upon OPT-MSN administration in vivo. The poor in vivo antitumor activity of OPT-MSNs despite efficient antitumor effects in vitro highlights that although MSN-based tumor-targeting strategies may hold therapeutic potential, clinical translation does not seem as straightforward as anticipated. Full article
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