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Molecular Research on Diabetes and Obesity

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 31 January 2025 | Viewed by 204

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Department of Physical Therapy, China Medical University, Taichung 404, Taiwan
Interests: exercise therapy; rehabilitation innovation; cardiopulmonary; stroke; noncommunicable diseases
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Special Issue Information

Dear Colleagues,

Obesity and diabetes are the most prevalent chronic metabolic diseases to develop cardiovascular diseases worldwide. The development or treatment of obesity and diabetes is influenced by multiple factors, including adipokines, inflammatory cytokines, growth hormones, insulin resistance, hyperlipidemia, physical activity, and lifestyles. Gaining insight into the cellular basis or signaling pathways of obesity and diabetes on various tissues could lay the foundations for the development of new therapeutic strategies.

This Special Issue aims to provide novel insights into pathological or therapeutic aspects of obesity and diabetes. To this end, we welcome experts in the field to contribute research articles and critical reviews on molecular, signaling pathways, and cellular mechanisms involved in the regulation, therapeutic effects, or treatment of obesity and diabetes.

Prof. Dr. Shin-Da Lee
Guest Editor

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Keywords

  • obesity
  • diabetes
  • hypothalamus
  • insulin resistance
  • glucose homeostasis
  • lipid metabolism
  • adipose tissue
  • cardiovascular tissue

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Published Papers (1 paper)

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Review

15 pages, 1181 KiB  
Review
Effects of Exercise Training on Cardiac Mitochondrial Functions in Diabetic Heart: A Systematic Review
by Iqbal Ali Shah, Shahid Ishaq, Shin-Da Lee and Bor-Tsang Wu
Int. J. Mol. Sci. 2025, 26(1), 8; https://doi.org/10.3390/ijms26010008 - 24 Dec 2024
Abstract
A diabetic heart is characterized by fibrosis, autophagy, oxidative stress, and altered mitochondrial functions. For this review, three databases (PubMed, EMBASE, and Web of Science) were searched for articles written in English from September 2023 to April 2024. Studies that used exercise training [...] Read more.
A diabetic heart is characterized by fibrosis, autophagy, oxidative stress, and altered mitochondrial functions. For this review, three databases (PubMed, EMBASE, and Web of Science) were searched for articles written in English from September 2023 to April 2024. Studies that used exercise training for at least 3 weeks and which reported positive, negative, or no effects were included. The CAMARADES checklist was used to assess the quality of the included studies, and ten studies (CAMARADES scores 4–7/10) were included. Nine studies showed that exercise training improved cardiac mitochondrial oxidative phosphorylation by decreasing ROS, increasing electron transport chain activity, and enhancing the production of ATP. Eight studies indicated that exercise training ameliorated mitochondrial biogenesis by increasing the levels of AMPK, PGC-1α, Akt, Irisin, and Sirtuin-III. Moreover, four studies focused on mitochondrial dynamics and concluded that exercise training helped decrease the levels of mitochondrial fission factor and dynamin-related protein- 1. Finally, six studies revealed improvements in mitochondrial physiological characteristics such as size, potential, and permeability. Our findings demonstrate the beneficial effects of exercise training on cardiac mitochondrial function in diabetic hearts. Exercise training improves cardiac mitochondrial physiological characteristics, oxidative phosphorylation, biogenesis, and dynamics. Full article
(This article belongs to the Special Issue Molecular Research on Diabetes and Obesity)
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