ijms-logo

Journal Browser

Journal Browser

Molecular Research in Chronic Kidney Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 April 2025 | Viewed by 1419

Special Issue Editor


E-Mail Website
Guest Editor
Department of Nephrology and Hypertension, Meir Medical Center, Kfar Saba 44281, Israel
Interests: chronic kidney disease; dialysis; genomics; proteomics; preeclampsia; molecular diagnosis

Special Issue Information

Dear Colleagues,

The worldwide prevalence of chronic kidney disease (CKD) is estimated to be 8–16%. CKD accounts for a substantial portion of the global health burden and is associated with in-creased morbidity and mortality. The incidence of CKD is expected to increase over time with the aging of the population and the increasing prevalence of diabetes and hypertension. The molecular mechanisms underlying CKD complications have proven to be distinct and complex and are associated with coagulation abnormalities, endothelial dysfunction, vascular calcification, the accumulation of uremic toxins, increased oxidative and metabolic stress, and inflammation. Understanding these mechanisms will potentially lead to the development of novel treatments able to slow the progression of underlying CKD.

This Special Issue, titled “Molecular Research in Chronic Kidney Disease”, aims to cover new insights into the molecular mechanisms of CKD and its complications. Basic and clinical research papers, as well as up-to-date review articles on this topic, are welcome to be submitted to this Special Issue.

Dr. Tali Zitman-Gal
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chronic kidney disease
  • hypertension
  • diabetes
  • preeclampsia
  • cell culture
  • RNA
  • protein
  • immunohistochemistry
  • inflammation
  • endothelial dysfunction

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

15 pages, 2292 KiB  
Review
HNF1B Transcription Factor: Key Regulator in Renal Physiology and Pathogenesis
by Eloísa Sánchez-Cazorla, Noa Carrera and Miguel Ángel García-González
Int. J. Mol. Sci. 2024, 25(19), 10609; https://doi.org/10.3390/ijms251910609 - 2 Oct 2024
Viewed by 992
Abstract
The HNF1B gene, located on chromosome 17q12, encodes a transcription factor essential for the development of several organs. It regulates the expression of multiple genes in renal, pancreatic, hepatic, neurological, and genitourinary tissues during prenatal and postnatal development, influencing processes such as nephrogenesis, [...] Read more.
The HNF1B gene, located on chromosome 17q12, encodes a transcription factor essential for the development of several organs. It regulates the expression of multiple genes in renal, pancreatic, hepatic, neurological, and genitourinary tissues during prenatal and postnatal development, influencing processes such as nephrogenesis, cellular polarity, tight junction formation, cilia development, ion transport in the renal tubule, and renal metabolism. Mutations that alter the function of Hnf1b deregulate those processes, leading to various pathologies characterized by both renal and extrarenal manifestations. The main renal diseases that develop are polycystic kidney disease, hypoplastic or dysplastic kidneys, structural abnormalities, Congenital Anomalies of the Kidney and Urinary Tract (CAKUT), and electrolyte imbalances such as hyperuricemia and hypomagnesemia. Extrarenal manifestations include Maturity-Onset Diabetes of the Young (MODY), hypertransaminasemia, genital and urinary tract malformations, Autism Spectrum Disorder (ASD), and other neurodevelopmental disorders. Patients with HNF1B alterations typically carry either punctual mutations or a monoallelic microdeletion in the 17q12 region. Future research on the molecular mechanisms and genotype–phenotype correlations in HNF1B-related conditions will enhance our understanding, leading to improved clinical management, genetic counseling, monitoring, and patient care. Full article
(This article belongs to the Special Issue Molecular Research in Chronic Kidney Disease)
Show Figures

Figure 1

Back to TopTop