Glutamine Metabolism in Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 October 2024 | Viewed by 122
Special Issue Editor
Interests: breast cancer; pathology; metabolism; prognosis; biomarkers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cancer, a major global health concern, exhibits significant clinical and biological heterogeneity, highlighting the need for personalised treatment approaches. Metabolic reprogramming has been recognised as a hallmark of cancer, and many aggressive cancer cells can become “glutamine-addicted”, relying heavily on this amino acid for rapid growth. Glutamine is used to replenish the tricarboxylic-acid (TCA) cycle and supplies carbon and nitrogen for the synthesis of nucleotides, amino acids, and glutathione. Its utilisation, via reductive carboxylation, is necessary for sustained proliferation/survival and is linked with resistance to certain drugs.
With a renewed interest in “oncometabolism”, the glutaminolysis pathway and cellular transport of glutamine via solute carriers are increasingly focused upon, with the aim of improving therapeutic efficacy and reducing resistance. Exploring this vital metabolic axis will allow us to gain valuable insights into cancer heterogeneity and pave the way for personalised treatment approaches for patients. This Special Issue therefore welcomes original research regarding all aspects of glutamine metabolism in cancer, including, but not limited to, cancer progression, redox homeostatsis, apopotosis, ferroptosis, the immune response, and the role of the tumour microenvironment.
Dr. Andrew R. Green
Guest Editor
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Keywords
- glutamine metabolism
- cancer
- oncometabolism
- cancer metabolism
- metabolic reprogramming
- personalised medicine
- therapeutic resistance
- drug targets
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