Immunology of Infection
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 20 October 2024 | Viewed by 1552
Special Issue Editor
Interests: sepsis; immunomodulation; infection; immunogenetics; clinical pharmacology; immunology in infectious diseases
Special Issue Information
Dear Colleagues,
According to the Sepsis-3 definition, sepsis is defined as a dysregulated host response to an infection. Immune response to an infection represents a dynamic and often dramatic trajectory ranging from initial hyperinflammation characterized primarily by disrupted endothelium, increased cytokine production, antigen presentation, and proinflammatory Th1, Th17 cells, respectively, to immunoparalysis characterized mainly by decreased cytokine production, endothelitis and increased anti-inflammatory Th2 and Treg cells. Immune response for the majority of patients lies between these two spectrums. Countless immunological pathways with myriads molecular patterns, receptors and cytokines interactions have been investigated in an effort to unravel the mysteries of immune response to an infection. This orchestrated host-pathogen interaction often is not only specific to the type of pathogen (i.e., viral, fungal, bacterial) but even associated with the type of infection. As immune response to an infection is the epitome of complexity and plea of biomarkers have been suggested, a combined strategy in order to expand current knowledge and design innovative tailored immunotherapy approach for future immunointervention is imperative.
In these Special Issues we welcome original contributions and review articles with the following (but not limited to) potential topics: immune host response to infection, molecular diagnosis of infection/sepsis, infection biomarkers, immune phenotype, immunomodulation.
Dr. Antigone J. Kotsaki
Guest Editor
Manuscript Submission Information
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Keywords
- sepsis
- molecular diagnosis
- cytokine
- biomarker
- immunotherapy
- inflammation
- infection
- immunoparalysis
