Molecular Genetics in Ovarian Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 31 March 2025 | Viewed by 94
Special Issue Editor
Interests: biological fluids; cancer; cancer biomarkers; cfDI; cfDNA; cfNA; copy number variation; ctDNA; ddPCR; disease-free survival; epigenetic; epigenetic sequencing; exosome; extracellular vesicle; genotyping; liquid biopsy; miRNA; mRNA; mutation; ncRNA; next- generation sequencing; overall survival; progression-free survival; recurrence-free survival; whole-exome sequencing
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Special Issue Information
Dear Colleagues,
Ovarian cancer (OC) is one of the deadliest malignancies in women worldwide due to its heterogeneity and high probability of recurrence, mainly due to chemotherapy resistance in its advanced stages (stages III and IV).
Common germline and somatic gene mutations in OCs such as BRCA and other driver mutations and their association with survival outcomes have recently been of great interest. In addition, OCs are characterised by genomic structural variations with frequent DNA gains and losses, making them a chromosomally unstable malignancy, especially the high-grade serous subtype. These structural changes are important mechanisms for the inactivation of tumour suppressors and cell cycle control genes in OCs.
In addition, there are an increasing number of studies demonstrating models based on differential gene expression that can help classify favourable and poor patient outcomes in patients with advanced-stage OC.
A better understanding of the mechanisms involved in these OC renegade cells’ metastasis and treatment response within the tumour microenvironment is therefore crucial for the implementation of rational oncotherapeutic strategies to prevent recurrence, ultimately improving patients' chances of survival.
Overall, this Special Issue highlights the recent advances in studies unravelling molecular trajectories toward a deeper understanding of molecular genetics and mechanistic pathways in OCs in terms of diagnosis, prognosis, therapeutic response, and chemotherapy resistance.
Dr. Bruna Scaggiante
Guest Editor
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Keywords
- chemotherapy resistance
- differential gene expression
- genomic structural variation
- ovarian cancer mutations
- ovarian cancer metastasis
- ovarian cancer treatment
- novel molecular targets
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