Bioactive Peptides: Synthesis, Functions, and Medicinal Chemistry Applications
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: 30 November 2024 | Viewed by 13
Special Issue Editor
Interests: drug design; peptides; peptidomimetics; molecular dynamics simulations; MM-GBSA; binding free energy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Peptides have emerged as promising therapeutic tools, with molecular weights and pharmacological properties that sit between traditional small molecule drugs and therapeutic proteins, such as monoclonal antibodies. Numerous peptides are clinically available for the treatment of various diseases, such as infections, cancer, osteoporosis, chronic pain, hormonal therapy, and skin aging. Additionally, peptides show significant potential for drug delivery applications and for disrupting protein–protein interactions (PPIs), displaying capabilities to be utilized in every biochemical pathway.
In recent years, we have seen substantial progress in the discovery and development of bioactive peptides, as testified by the increasing number of deposited patents. Advances that have been made include the following: genome mining, the development of new chemical methods for peptide cyclization, efficient synthesis of long peptides through peptide ligation, the creation of peptide libraries for high-throughput screening, and an enhancement of our understanding of peptide intracellular delivery and metabolic protection.
Lead by Prof. Dr. Giovanni Grazioso and assisted by our Topical Advisory Panel Member Dr. Enrico M. A. Fassi (University of Milan), this Special Issue focuses on recent studies contributing to our understanding of peptides on their discovery, bio- and organic synthesis, delivery, improvement of their pharmacokinetic properties, conjugation, and any other medicinal chemistry aspect.
We welcome the submissions of original research articles and reviews on these and related topics to this Special Issue.
Prof. Dr. Giovanni Grazioso
Guest Editor
Manuscript Submission Information
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Keywords
- peptides
- protein–protein interactions (PPIs)
- peptide intracellular delivery
