Recent Advancements in Natural and Synthetic DNA/RNA G-Quadruplex Binders
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 20 July 2025 | Viewed by 1431
Special Issue Editor
Special Issue Information
Dear Colleagues,
Nucleic acid fragments rich in guanosine form characteristic spatial structures called G-quadruplexes. These structures are formed as a result of the interaction of four guanosines, stabilized by metal ions, e.g., Na+ or K+, and are involved in a number of key genome functions, e.g., transcription and replication. The compounds, both of synthetic or natural origins, that are able to effectively bind G-quadruplex may be of potential use in the fields of cancer therapy, antiviral therapy, and neuropharmacology, or to design the G-quadruplex probes. As the G-quadruplex ligands are considered to be of potential use in targeting various diseases, the interest in the area of research focused on these structures has been substantially increasing. This Special Issue welcomes papers covering all aspects of G-quadruplex ligands: their synthesis, search for effective natural ligands, stabilities of the G-quadruplex-ligand species, and mechanism of the interaction between the ligands and G-quadruplexes, as well as those focused on the pharmaceutic potential of the ligands. Interested authors are invited to submit manuscripts reporting the investigation of physicochemical and/or biochemical properties of G-quadruplex-ligand species with computational and/or physicochemical methods, as well as reviews in this area of research.
Dr. Magdalena Frańska
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- guanine
- guanosine
- G-tetrad
- G-quadruplex-interactive agent
- binding agent
- nucleic acids
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
