Steroidal Anticancer Agents for Treating Gynecological Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 2093
Special Issue Editors
Interests: steroidal anticancer agents; cell cycle blockade; antimetastatic activity; tubulin polymerization; metastasis pathways; HPV-associated cancer
Special Issues, Collections and Topics in MDPI journals
Interests: steroid synthesis; core modification; secosteroids; homosteroids; molecular mechanics; molecular dynamics; drug design
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Nearly 60 years ago the first scientific article about cancer cell proliferation inhibiting effect of cardiac glycosides was published. Since then the scientific interest has not declined in connection with novel anticancer agents with widely modifiable sterane skeleton. Thanks to the permanent and intensive research work in this field, numerous steroidal anticancer agents (e.g., fulvestrant, estramustin, cyproterone and exemestane) have become significant members of antitumor protocols. In addition, substantially diverse anticancer mechanisms of action have been described such as steroidal receptor antagonism, enzyme inhibition and surprising direct antiproliferative activity as well as promising inhibitory effect on multi-drug resistance. Therefore, these molecules still deserve outstanding attention in the field of anticancer research.
This Special Issue of the International Journal of Molecular Sciences entitled “Steroidal Anticancer Agents for Treating Gynecological Cancer”, will focus on recent advances in newly synthesized compounds with sterane skeleton and their anticancer effect, such as structure-activity relationships, molecular mechanism of antitumor and antimetastatic effect, mechanisms of multi-drug resistance reversal features and investigation of the structural background of the anticancer activitiy at atomic level using computational simulation. Contributions on these related topics are welcomed, including original research and full reviews. We also very much welcome tasks of postdocs, PhD students, and young researchers.
Dr. Renáta Minorics
Dr. Erzsébet Mernyák
Guest Editors
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Keywords
- breast/ovarian/cervical/endometrial cancer
- synthetic/semi-synthetic analogues
- structure determination
- estrane/pregnane/androstane derivatives
- cell cycle arrest
- cell death induction
- tubulin-microtubule system
- intracellular/membrane steroid hormone receptors
- metastasis signaling pathway
- structure-activity relationship
- computational simulation
- molecular docking/modeling
- multi-drug resistance reversal effect
- in vitro and in vivo approach
- enzyme inhibition
