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Glycosaminoglycans, 2nd Edition
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Glycosaminoglycans, 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Macromolecules".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 826

Special Issue Editors

Prof. Dr. Chiara Schiraldi

E-Mail Website
Guest Editor
Department of Experimental Medicine, University of Campania L. Vanvitelli, Via de Crecchio 7, 80138 Naples, Italy
Interests: glycosaminoglycans; hyaluronic acid; chondroitin; microbial polysaccharide; biosynthetic pathways; GAG-based biomaterials; extracellular matrix; cell-macromolecules interactions
Special Issues, Collections and Topics in MDPI journals
Dr. Donatella Cimini

E-Mail Website
Guest Editor
Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania Luigi Vanvitelli, Via Vivaldi, 43 81100 Caserta, Italy
Interests: metabolic engineering; microbial fermentation; microbial glycosaminoglycans (GAGs) and GAG-like polysaccharides; chondroitin; bioprocess development from lab to pilot scale; probiotics; organic acids; waste biomass valorization
Special Issues, Collections and Topics in MDPI journals
Dr. Annalisa La Gatta

E-Mail Website
Guest Editor
Department of Experimental Medicine, University of Campania L. Vanvitelli, Via de Crecchio 7, 80138 Naples, Italy
Interests: glycosaminoglycans; hyaluronic acid; GAGs in medical devices; GAGs chemical modifications; GAG hydrodynamic characterization; GAG-based hydrogels’ stability, rheology, and interaction with cells; GAG mucoadhesivity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Following the success of the first volume on “Glycosaminoglycans”, we are pleased to announce the launch of a second volume, focusing on the same topic.

Glycosaminoglycans (GAGs) are attracting an increasing amount of scientific interest due to their structural features, bioactivity, and biochemical role in different physiological and pathological conditions. Structural modifications of well-known GAGs are found in natural sources and/or obtained through custom tailored semisynthetic approaches. The aim of this Special Issue is to cover, with the help and expertise of contributing authors, three main aspects of the ongoing research and innovation on this topic: a) novel biotechnological and biosynthetic strategies to obtain GAG-like molecules; b) innovative approaches in the modification and characterization of GAGs; and c) advances in unraveling and exploiting GAGs functional roles in biomedical sciences, with a specific interest in tissue engineering.

Also welcome are studies focusing on innovative aspects related to biomacromolecules’ interaction with specific cells targets, towards the assessment of GAGs as effectors in the biochemical cascade.

Prof. Dr. Chiara Schiraldi
Dr. Donatella Cimini
Dr. Annalisa La Gatta
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Keywords

  • biosynthesis of glycosaminoglycans
  • hyaluronan
  • chondroitin sulfate
  • heparin
  • modified GAGS
  • GAG bioactivity
  • GAGs as biomarkers
  • novel characterization methods
  • GAGs as drug or drug carriers
  • GAG= interaction with cells
  • in vitro cell-based assays
  • innovative biofabrication methodology based on GAGs
  • 3D scaffolds based on GAGs

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Published Papers (1 paper)

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Research

17 pages, 3472 KiB  
Article
Alterations in the Structure, Composition, and Organization of Galactosaminoglycan-Containing Proteoglycans and Collagen Correspond to the Progressive Stages of Dupuytren’s Disease
by Luiz Guilherme S. Lenzi, João Baptista Gomes dos Santos, Renan P. Cavalheiro, Aline Mendes, Elsa Y. Kobayashi, Helena B. Nader and Flavio Faloppa
Int. J. Mol. Sci. 2024, 25(13), 7192; https://doi.org/10.3390/ijms25137192 - 29 Jun 2024
Viewed by 336
Abstract
Dupuytren’s disease (DD) is a prevalent fibroproliferative disorder of the hand, shaped by genetic, epigenetic, and environmental influences. The extracellular matrix (ECM) is a complex assembly of diverse macromolecules. Alterations in the ECM’s content, structure and organization can impact both normal physiological functions [...] Read more.
Dupuytren’s disease (DD) is a prevalent fibroproliferative disorder of the hand, shaped by genetic, epigenetic, and environmental influences. The extracellular matrix (ECM) is a complex assembly of diverse macromolecules. Alterations in the ECM’s content, structure and organization can impact both normal physiological functions and pathological conditions. This study explored the content and organization of glycosaminoglycans, proteoglycans, and collagen in the ECM of patients at various stages of DD, assessing their potential as prognostic indicators. This research reveals, for the first time, relevant changes in the complexity of chondroitin/dermatan sulfate structures, specifically an increase of disaccharides containing iduronic acid residues covalently linked to either N-acetylgalactosamine 6-O-sulfated or N-acetylgalactosamine 4-O-sulfated, correlating with the disease’s severity. Additionally, we noted an increase in versican expression, a high molecular weight proteoglycan, across stages I to IV, while decorin, a small leucine-rich proteoglycan, significantly diminishes as DD progresses, both confirmed by mRNA analysis and protein detection via confocal microscopy. Coherent anti-Stokes Raman scattering (CARS) microscopy further demonstrated that collagen fibril architecture in DD varies importantly with disease stages. Moreover, the urinary excretion of both hyaluronic and sulfated glycosaminoglycans markedly decreased among DD patients.Our findings indicate that specific proteoglycans with galactosaminoglycan chains and collagen arrangements could serve as biomarkers for DD progression. The reduction in glycosaminoglycan excretion suggests a systemic manifestation of the disease. Full article
(This article belongs to the Special Issue Glycosaminoglycans, 2nd Edition)
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