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Microbiome and Immunology in Gynecologic Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 20 June 2025 | Viewed by 2020

Special Issue Editor

Special Issue Information

Dear Colleagues,

The research featured in this Special Issue offers invaluable insights into the physiological functions, pathogenesis, and pathophysiology relevant to gynecological health and disease. We are particularly focused on the role the human the microbiome and immune system play in women’s health. Examples of topics of interest include the impact of the female reproductive microbiome on female reproductive function; infertility and gynecological cancers; as well as microbial infections and immune tolerance during pregnancy. Some immune cells in the maternal immune system, such as uterine natural killer cells (uNK), killer immunoglobulin-like receptors (KIR) and human leukocyte antigens (HLA), are also of interest.

The International Journal of Molecular Sciences (IJMS) provides a platform for scientists to disseminate their high-quality scientific findings in this emerging field of the intricate connections between the microbiome, immune system, and various gynecological entities. Researchers are encouraged to submit articles that incorporate biomolecular experiments or data, rather than purely clinical or model-based studies.

By exploring the biomolecular data and experimental evidence, scientists have the opportunity to unveil potential pathways and future therapeutic strategies.

By advancing scientific knowledge, this Special Issue of IJMS contributes to the investigation of pathways, accurate diagnosis, and development of novel therapeutic approaches to promote gynecological health.

Dr. Panagiotis Christopoulos
Guest Editor

Manuscript Submission Information

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Keywords

  • microbiome
  • immunology
  • gynecological diseases
  • cancer
  • PCOS
  • hormones
  • infertility

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Published Papers (1 paper)

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Review

13 pages, 690 KiB  
Review
Semen Microbiome, Male Infertility, and Reproductive Health
by Dimitra Chatzokou, Ermioni Tsarna, Efstathia Davouti, Charalampos S Siristatidis, Smaragdi Christopoulou, Nikolaos Spanakis, Athanasios Tsakris and Panagiotis Christopoulos
Int. J. Mol. Sci. 2025, 26(4), 1446; https://doi.org/10.3390/ijms26041446 - 9 Feb 2025
Cited by 2 | Viewed by 1448
Abstract
The semen microbiome, once believed to be sterile, is now recognized as a dynamic ecosystem containing a diverse range of microorganisms with potential implications for male fertility and reproductive health. We aimed to examine the relationship between the semen microbiome, male infertility, and [...] Read more.
The semen microbiome, once believed to be sterile, is now recognized as a dynamic ecosystem containing a diverse range of microorganisms with potential implications for male fertility and reproductive health. We aimed to examine the relationship between the semen microbiome, male infertility, and reproductive outcomes, highlighting the transformative role of next generation sequencing techniques and bioinformatics in exploring this intricate interaction, and we present a critical review of the published literature on this issue. Current evidence suggests a complex association between the composition of the semen microbiome and male fertility, with certain bacterial genera, such as Lactobacillus and Prevotella that exert opposing effects on sperm quality and DNA integrity. In addition, the influence of the semen microbiome extends beyond natural fertility, affecting assisted reproductive technologies and pregnancy outcomes. Despite considerable progress, challenges remain in standardizing methodologies and interpreting findings. In conclusion, we identify the lack of a definitive management proposal for couples presenting with this phenomenon, and we underline the need for an algorithm and indicate the questions raised that point toward our goal for a strategy. Continued research is essential to clarify the role of the semen microbiome in male reproductive health and to advance the development of personalized fertility management approaches. Full article
(This article belongs to the Special Issue Microbiome and Immunology in Gynecologic Diseases)
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