Genome Assembly
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Informatics".
Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 2441
Special Issue Editor
Special Issue Information
Dear Colleagues,
De novo genome assembly is one of the oldest problems in bioinformatics, dating back to the 1980s. Despite significant development over the years, this remains a difficult task. One of the key complications of the assembly problem is that repetitive sequences induce several paths in the assembly graph by linking different genomic loci. As a result, multiple genome reconstructions are feasible, but only one is correct. The genome-path problem, as well as the huge advances in sequencing and genome-mapping technologies, have motivated the development of a variety of computational and experimental techniques for cracking genome sequences.
Research in genome sequencing and de novo assembly of complex genomes, metagenomes, and transcriptomes, as well as computational algorithms for haplotype-resolved assembly, sequence validation, repeat identification, sequence error correction, assembly-based variant calling, alignment-free methods, and genome finishing, are all covered in this Special Issue, "Advances in genome assembly," which is now open for submissions. The submission of experimental and bioinformatic articles, up-to-date reviews, and commentaries associated with the genome-assembly problem are also encouraged.
Dr. Alex Di Genova
Guest Editor
Manuscript Submission Information
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Keywords
- genome assembly
- genome sequencing
- haplotype resolution
- variant calling
- repeat identification
- sequence validation
- computational tools
- metagenomes
- transcriptomes
