Physiological and Pathological Hypoxia: The Battle between the Protective and Deleterious Effects of Oxygen Deprivation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 10 December 2024 | Viewed by 62
Special Issue Editors
Interests: hypoxia; hyperoxia; cardioprotection; brain protection; reoxygenation, molecular mechanisms; apoptosis; autophagy; erythropoietin; nitric oxide; animal models; exercise; high altitude; hemoglobin; oxygen carriers; blood oxygen transport
Special Issues, Collections and Topics in MDPI journals
Interests: cell physiology and differentiation; adaptive physiology; neurodegeneration; cancer biology; functional proteomics
Special Issues, Collections and Topics in MDPI journals
Interests: clinical biochemistry; liquid chromatography; reference methods; hormones and vitamins; lipidomics; metabolomics
Interests: drones; telemedical support; search and rescue operations; occupational accidents; mountain rescue; mental health conditions; acute mountain sickness; hypoxia; avalanche survival; hypothermia; cardiopulmonary resuscitation (CPR); altitude effects; frostbite; heat-flux thermometer; COVID-19 pandemic and search and rescue operations
Special Issue Information
Dear Colleagues,
Hypoxia generally stems from any situation whereby the oxygen supply to tissues does not meet the demand. Either systemic or local hypoxia may thus be due to an array of causes that span from physiological (e.g., high altitude) or pathological (e.g., pulmonary, haematological, oncological, or cardiovascular diseases). While the body may be thought to be able to orchestrate defences against physiological hypoxia via survival responses, pathological hypoxia often represents a more lethal challenge characterized by high mortality and morbidity scores. Erythropoiesis may represent a paradigmatic example of the dual response to hypoxia: while physiological hypoxia increases circulating haemoglobin, enhancing oxygen transport, pathological hypoxia is often associated with anaemia, probably for impaired iron handling by hepcidin due to inflammation.
In this Special Issue, we are calling for contributions aimed at integrating the differential responses to physiological and pathological hypoxia in in vivo and in vitro models. Such responses may concern any body system and any subcellular function/compartment, as well as any signalling pathway (just to name a few, the pathways underlying the activation of oxygen sensors, the glycolytic switch, the concept of “happy hypoxia”, the inflammatory and immune systems, the handling of calcium, iron, and other ions, the antioxidant response, the lipidomic, metabolomic, and genomic changes, etc). Contributions investigating the occurrence of phenomena linked to hormesis, e.g., hypoxic preconditioning in all its forms, from cognitive to molecular, will also be highly welcome.
Prof. Dr. Michele Samaja
Prof. Dr. Michele Maffia
Prof. Dr. Rita Paroni
Dr. Giacomo Strapazzon
Guest Editors
Manuscript Submission Information
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Keywords
- physiological hypoxia
- pathological hypoxia
- hypoxia
- signalling pathway
- inflammation
- oxygen transport
