Molecular Biology of Prostate Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 10564
Special Issue Editor
Special Issue Information
Dear Colleagues,
Prostate cancer (PC) is the most common type of cancer among men and the second death rate of male cancer worldwide, with a new 1.4 million cases of incidence and 375,304 mortalities in 2020.
The etiology of prostate cancer remains largely unknown; in addition to aging and ethnicity, genetic and environmental factors are believed to contribute to the development of prostate cancer. Prostate cancer is characterized as molecularly heterogeneous, and its natural history is highly variable, which leads to different treatment modalities from active surveillance to aggressive treatment. Understanding these biological alterations behind is crucial in determining the course of the disease and providing a guide for therapy. Although most prostate cancers initially respond to androgen deprivation therapy (ADT), they gradually develop resistance and progress to castration-resistant prostate cancer (CRPC), which eventually becomes lethal. Understanding the mechanisms of CRPC will help us to develop novel treatment strategies and predict drug response toward precision medicine.
We invite researchers working on the identification of innovative strategies targeting PC to contribute to this Special Issue. Original research articles or reviews on ADT or CRPC related to the molecular and cellular mechanisms through which Prostate cancer can be treated are welcome. Articles with insights on biological and therapeutic perspectives are especially welcome.
Prof. Dr. Yukio Naya
Guest Editor
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Keywords
- prostate cancer
- ADT
- CRPC
- drug discovery
- precision medicine
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