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Collagen-Based Biomaterials in Tissue Engineering and Regenerative Medicine

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Macromolecules".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 35

Special Issue Editors


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Guest Editor
Department of Composites and Carbon Materials, the Institute of Rock Structure and Mechanics of the Czech Academy of Sciences, V Holesovickach 94/41, 18209 Prague 8, Czech Republic
Interests: analytical chemistry; protein structure; biological material; collagen; natural polymers; tissue engineering; regenerative medicine

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Guest Editor
Faculty of Mechanical Engineering, University of Maribor, Smetanova ulica 17, 2000 Maribor, Slovenia
Interests: (bio)polymers; modification and structuring within particle-, membrane-, and 3D scaffolds shape; modification and compounding of nanocellulose from bacterial and plant origin; aerogels processing by freeze/drying(thawing) tool; GTR membranes; analysis (spectroscopy, confocal microscopy)
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Department of Tissue Engineering, Institute of Experimental Medicine of the Czech Academy of Sciences, 14220 Prague, Czech Republic
Interests: tissue engineering; regenerative medicine; nanofibres; composite scaffolds; drug delivery systems
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The current technological advances in biochemistry, molecular and cell biology, material sciences, and molecular medicine are significantly expanding the current opportunities in tissue engineering (TE) and regenerative medicine and lead to the development of new advanced biomaterials with the potential for more effective and faster treatment of tissue defects.

Many of these materials are based on collagen, the key molecule forming the human and animal bodies, the basic component of the extracellular matrix (ECM), and about 30% of all proteins in the body. Collagen is responsible for the proper functionality of various types of cells and tissues, plays an important role in wound healing, and belongs to one of the most attractive biopolymers used in TE due to its biocompatibility, biodegradability, low antigenicity, and toxicity. In the form of thin layers, nanofibers, 3D cell scaffolds, etc., collagen is a frequent component of composite biodegradable materials that are being tested and used as implant coatings, fillers, and replacements for tissue defects, in wound treatment, or even in targeted drug delivery

Collagen crosslinks, glycosaminoglycans, proteoglycans, and various adhesive molecules bound to collagen significantly influence the structure of individual collagen types and the  arrangement, reactivity, physico-chemical, biomechanical, and functional properties of connective tissues. In addition, attention should be paid to various metabolic and genetically determined diseases and clinical states related to structural changes and modifications of the collagen molecule. In fact, there are still some challenges connected to the collagen isolation and processing, the biodegradability of the collagen-based biomaterials, technical, immunological, cellular response, or even surgical issues that need to be addressed before newly developed materials and products find practical application in clinical practice.

Therefore, we have decided to prepare this Special Issue of IJMS on “Collagen-Based Biomaterials in Tissue Engineering and Regenerative Medicine” to summarize all the mentioned aspects and share the current multidisciplinary knowledge on collagen and related molecules, their analyses and applications in TE, and we would be pleased if you could add your experience and expertise on this topic within this proceedings.

This Special Issue is supervised by Dr. Martin Braun, Dr. Selestina Gorgieva, and Dr. Eva Filova, and assisted by our Topical Advisory Panel Member Dr. Lucie Wolfová,  (Department of Tissue Engineering, Institute of Experimental Medicine of the Czech Academy of Sciences, 14220 Prague, Czech Republic).

Dr. Martin Braun
Dr. Selestina Gorgieva
Dr. Eva Filova
Guest Editors

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Keywords

  • collagen
  • tissue engineering
  • advanced biomaterials
  • biodegradable composites
  • scaffolds
  • protein structure
  • biochemical analysis
  • material characterization
  • medical application
  • gelatine

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