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Teleost in Biomedical Research
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Teleost in Biomedical Research

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 4452

Special Issue Editors

Prof. Dr. Antonino Germanà

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Guest Editor
Zebrafish Neuromorphology Laboratory, Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy
Interests: immunohistochemistry; electron microscopy; neurobiology; sensory system; zebrafish; obesity
Dr. Marialuisa Aragona

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Guest Editor
Zebrafish Neuromorphology Laboratory, Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy
Interests: neurosciences; translational medicine; teleosts; zebrafish; nothobranchius sp; veterinary anatomy; comparative anatomy; immunohistochemistry; molecular biology

Special Issue Information

Dear Colleagues,

Humans and fish share several affinities from a morphological and functional perspective, making fish valuable models for studying various biological processes and diseases. Both fish and humans exhibit similar organ systems, including the heart, liver, intestine, and nervous system, allowing for comparative studies of organ function and development. Moreover, genetic studies on fish reveal a high degree of similarity to humans. Fish are perfect for researching both organismic and molecular evolution due to their evolutionary position in relation to other vertebrates and their capacity for environmental adaptation. It turned out that fish are ideal experimental models for research in embryology, neurobiology, endocrinology, and environmental biology. Fish are increasingly employed as experimental models thanks to research methods that allow scientists to produce isogenic lines in a single generation, generate and maintain mutants, cultivate cells, and insert cloned genes into embryos. Some teleosts undergo rapid and transparent embryonic development, enabling researchers to observe and analyze developmental processes in real time. Small teleosts are suitable for large-scale experiments thanks to their size and cost-effective maintenance. Overall, the use of fish in scientific research presents a versatile and efficient approach to advancing our understanding of fundamental biological and pathological mechanisms.

This Special Issue of the International Journal of Molecular Sciences on “Teleost in Biomedical Research” is supervised by Prof. Dr. Antonino Germanà and Dr. Marialuisa Aragona, and supported by Dr. Caterina Porcino (University of Messina, Italy). We invite you to contribute original research articles, comprehensive reviews, communications, case reports, etc., to this Special Issue for peer review and possible publication.

Prof. Dr. Antonino Germanà
Dr. Marialuisa Aragona
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fish
  • teleost
  • experimental model
  • translational research
  • biomedicine
  • comparative studies

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Published Papers (2 papers)

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Research

15 pages, 11592 KiB  
Article
Piezo 1 and Piezo 2 in the Chemosensory Organs of Zebrafish (Danio rerio)
by Marialuisa Aragona, Kamel Mhalhel, Marzio Cometa, Gianluca Antonio Franco, Giuseppe Montalbano, Maria Cristina Guerrera, Maria Levanti, Rosaria Laurà, Francesco Abbate, José A. Vega and Antonino Germanà
Int. J. Mol. Sci. 2024, 25(13), 7404; https://doi.org/10.3390/ijms25137404 - 5 Jul 2024
Cited by 1 | Viewed by 3437
Abstract
The ion channels Piezo 1 and Piezo 2 have been identified as membrane mechano-proteins. Studying mechanosensitive channels in chemosensory organs could help in understanding the mechanisms by which these channels operate, offering new therapeutic targets for various disorders. This study investigates the expression [...] Read more.
The ion channels Piezo 1 and Piezo 2 have been identified as membrane mechano-proteins. Studying mechanosensitive channels in chemosensory organs could help in understanding the mechanisms by which these channels operate, offering new therapeutic targets for various disorders. This study investigates the expression patterns of Piezo proteins in zebrafish chemosensory organs. For the first time, Piezo protein expression in adult zebrafish chemosensory organs is reported. In the olfactory epithelium, Piezo 1 immunolabels kappe neurons, microvillous cells, and crypt neurons, while Calretinin is expressed in ciliated sensory cells. The lack of overlap between Piezo 1 and Calretinin confirms Piezo 1’s specificity for kappe neurons, microvillous cells, and crypt neurons. Piezo 2 shows intense immunoreactivity in kappe neurons, one-ciliated sensory cells, and multi-ciliated sensory cells, with overlapping Calretinin expression, indicating its olfactory neuron nature. In taste buds, Piezo 1 immunolabels Merkel-like cells at the bases of cutaneous and pharyngeal taste buds and the light and dark cells of cutaneous and oral taste buds. It also marks the dark cells of pharyngeal taste buds and support cells in oral taste buds. Piezo 2 is found in the light and dark cells of cutaneous and oral taste buds and isolated chemosensory cells. These findings provide new insights into the distribution of Piezo channels in zebrafish chemosensory organs, enhancing our understanding of their sensory processing and potential therapeutic applications. Full article
(This article belongs to the Special Issue Teleost in Biomedical Research)
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16 pages, 2525 KiB  
Article
Comparative Study of Condensed and Hydrolysable Tannins during the Early Stages of Zebrafish Development
by Alessandra La Pietra, Roberta Imperatore, Elena Coccia, Teresa Mobilio, Ida Ferrandino and Marina Paolucci
Int. J. Mol. Sci. 2024, 25(13), 7063; https://doi.org/10.3390/ijms25137063 - 27 Jun 2024
Viewed by 655
Abstract
In this study, we present data on the effects of condensed tannins (CTs) and hydrolysable tannins (HTs), polyphenols extracted from plants, at different concentrations on zebrafish development to identify the range of concentrations with toxic effects. Zebrafish embryos were exposed to CTs and [...] Read more.
In this study, we present data on the effects of condensed tannins (CTs) and hydrolysable tannins (HTs), polyphenols extracted from plants, at different concentrations on zebrafish development to identify the range of concentrations with toxic effects. Zebrafish embryos were exposed to CTs and HTs at two different concentration ranges (5.0–20.0 μgL−1 and 5.0–20.0 mgL−1) for 72 h. The toxicity parameters were observed up to 72 h of treatment. The uptake of CTs and HTs by the zebrafish larvae was assessed via HPLC analysis. A qRT-PCR analysis was performed to evaluate the expressions of genes cd63, zhe1, and klf4, involved in the hatching process of zebrafish. CTs and HTs at 5.0, 10.0, and 20.0 μgL−1 were not toxic. On the contrary, at 5.0, 10.0, and 20.0 mgL−1, HTs induced a delay in hatching starting from 48 h of treatment, while CTs showed a delay in hatching mainly at 48 h. The analysis of gene expression showed a downregulation in the group exposed to HTs, confirming the hatching data. We believe that this study is important for defining the optimal doses of CTs and HTs to be employed in different application fields such as the chemical industry, the animal feed industry, and medical science. Full article
(This article belongs to the Special Issue Teleost in Biomedical Research)
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