Inflammatory Bowel Disease: Focus on Molecular Research
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 1387
Special Issue Editors
Interests: inflammatory bowel disease; inflammation; inflammation resolution; macrophage biology; macrophage efferocytosis; oxidized lipids; LC-MS/MS; intestinal epithelial biology; intestinal epithelium under homeostasis and repair; intestinal barrier function; GI mucosal immunity
Interests: inflammatory bowel disease; C. difficile infection; metabolic diseases; Crohn’s disease; intestinal fibrosis
Special Issue Information
Dear Colleagues,
Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disorder of the GI tract that affects nearly 1 in 100 people in the US and exhibits increasing worldwide prevalence. The etiology of IBD is incompletely understood, but involves a dysregulated immune response to gut microbiota engendered by environmental triggers in genetically susceptible individuals. Modern molecular techniques have partially elucidated the underlying mechanisms of this multifactorial disease. GWAS studies have implicated over 200 genetic susceptibility factors in IBD, whose underlying functions are still being investigated. Shotgun metagenomic and 16s RNA sequencing have characterized microbial dysbiosis associated with IBD. Immunophenotyping, spatial transcriptomics, and whole- and single-cell RNA sequencing have shed light on the interplay of immune cells within affected tissue, while enabling the phenotyping of IBD patients. Proteomic, lipidomic, and metabolomic analyses have identified circulating biomarkers and possible therapeutic targets. Nonetheless, while there exist several recently approved biologic and targeted therapies for IBD, these exhibit a consistent therapeutic ceiling of approximately 50%. The identification of additional biomarkers, actionable pathways, and novel therapeutics is needed.
This Special Issue aims to report the latest findings in the molecular biology of IBD. These studies can involve any modern molecular technique, such as proteomic, phosphoproteomic, lipidomic, or metabolomic analyses; genetic and gene expression analyses including spatial transcriptomics and single-cell RNA sequencing; mechanistic investigations involving animal and organoid models; and microbiological analyses including 16s RNA or shotgun metagenomic sequencing.
Dr. David Meriwether
Dr. Hon Wai Koon
Guest Editors
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Keywords
- inflammatory bowel disease
- gut microbiota
- genomic sequencing
- proteomic
- lipidomic
- metabolomic
- therapy
- biomarker
- animal and organoid model
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