Tumor Specific Immunotherapeutic Targets
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 30 January 2025 | Viewed by 61
Special Issue Editor
Interests: extracellular matrix; proteoglycans; immunotherapy; metastasis; angiogenesis; cell-matrix interactions; cancer stem cells; cell migration/invasion; tumour microenvironment
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The disclosure of ideal targets for passive immunotherapy directed against the cancer cells of solid and hematologic tumours or their microenvironment (i.e., the tumour ecosystem) is challenging due to the difficulty in unveiling discrete molecules that are truly exclusive components of the tumour lesion. In hematologic neoplasia, this difficulty is further exacerbated by the need to target surface-associated antigens that are electively expressed by neoplastic lymphocytes/leukocytes.
Although most immunotherapeutics that are currently clinically approved for cancer treatment target fairly ubiquitous surface molecules, and their anti-tumour efficacy relies on their exuberant expression compared to that found on healthy cells, a recurrent clinical caveat is the high levels of collateral toxicity detected in patients over the years (post-treatment). This limitation incites the search for truly tumour-specific antigens that could serve the development of effective antibody drugs.
Multi-omics approaches and the creation of publicly accessible data bases compiling information derived from these approaches are affording a formidable opportunity to uncover highly selective cancer markers. This Special Issue seeks original manuscripts, classical reviews, perspectives discussing recently published findings, and well-circumstantiated hypothesis articles treating novel and previously identified immunotherapeutic targets, novel methods and technologies to identify them and/or ways to demonstrate the predicted efficacy. Provided that they are fully compatible with the scope of the Special Issue, contributions from computational science, physics and bioengineering fields are welcome.
Prof. Dr. Roberto Perris
Guest Editor
Manuscript Submission Information
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Keywords
- immunotherapy
- immunotherapeutics
- tumour-specific antigens
- immunotherapeutic targets
- multi-omics approaches
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