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Research on Transcriptional Regulation in Reproductive Biology

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (31 August 2024) | Viewed by 840

Special Issue Editor

Department of Animal Anatomy and Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, Oczapowskiego St. 1A, 10-719 Olsztyn, Poland
Interests: reproductive biology; molecular biology; signaling pathways; cell biology; cell culture; biotechnology; cancer biology; pharmacology; genetic engineering; signal transduction

Special Issue Information

Dear Colleagues,

We are pleased to announce that we have launched a new Special Issue entitled “Research on Transcriptional Regulation in Reproductive Biology”. Knowledge of molecular mechanisms underlying reproductive processes is fundamental for the progress in the approaches constituting the groundwork for future research in reproductive biology. Transcriptional regulation is a crucial biological process that enables cellular response to a variety of intra- and extra-cellular signals, to maintain the proper functioning of the cell throughout its lifetime. This Special Issue welcomes any submissions that push forward our understanding of transcriptional regulations in female and male reproduction in both model organisms and human studies. We welcome studies presenting results at the molecular level that shed light on the molecular mechanisms of ovarian, uterine and testicular biology, control of reproduction, gametogenesis, fertilization, embryo development, embryo-uterus interaction, reproductive development, reproductive immunology and medicine etc. Research areas may include studies concerning both physiology as well as pathology of reproductive processes. Original research articles (in vitro and in vivo studies) and reviews are welcome. We look forward to receiving your contributions.

Dr. Anna Nynca
Guest Editor

Manuscript Submission Information

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Keywords

  • reproductive biology
  • molecular research
  • transcriptional regulations
  • signaling pathways
  • gene expression
  • cell biology

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Published Papers (1 paper)

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Research

14 pages, 2840 KiB  
Article
Regulation of Bone Morphogenetic Protein Receptor Type II Expression by FMR1/Fragile X Mental Retardation Protein in Human Granulosa Cells in the Context of Poor Ovarian Response
by Xuan Phuoc Nguyen, Adriana Vilkaite, Ulrike Bender, Jens E. Dietrich, Katrin Hinderhofer, Thomas Strowitzki and Julia Rehnitz
Int. J. Mol. Sci. 2024, 25(19), 10643; https://doi.org/10.3390/ijms251910643 - 3 Oct 2024
Viewed by 465
Abstract
Fragile X mental retardation protein (FMRP) is a translational repressor encoded by FMR1. It targets bone morphogenetic protein receptor type II (BMPR2), which regulates granulosa cell (GC) function and follicle development. However, whether this interaction affects folliculogenesis remains unclear. Therefore, this study [...] Read more.
Fragile X mental retardation protein (FMRP) is a translational repressor encoded by FMR1. It targets bone morphogenetic protein receptor type II (BMPR2), which regulates granulosa cell (GC) function and follicle development. However, whether this interaction affects folliculogenesis remains unclear. Therefore, this study investigated the potential effect of FMRP-BMPR2 dysregulation in ovarian reserves and infertility. COV434 cells and patient-derived GCs were used to evaluate FMRP and BMPR2 expression. Similarly, FMR1, BMPR2, LIMK1, and SMAD expression were evaluated in GCs with normal (NOR) and poor (POR) ovarian responses. FMRP and BMPR2 were expressed in both cell types. They were co-localized to the nuclear membrane of COV434 cells and cytoplasm of primary GCs. FMR1 silencing increased the mRNA and protein levels of BMPR2. However, the mRNA levels of FMR1 and BMPR2 were significantly lower in the POR group. FMR1 and BMPR2 levels were strongly positively correlated in the NOR group but weakly correlated in the POR group. Additionally, SMAD9 expression was significantly reduced in the POR group. This study highlights the crucial role of FMR1/FMRP in the regulation of BMPR2 expression and its impact on ovarian function. These findings indicate that the disruption of FMRP-BMPR2 interactions may cause poor ovarian responses and infertility. Full article
(This article belongs to the Special Issue Research on Transcriptional Regulation in Reproductive Biology)
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