The Role of P2X7 Receptor in Human Health and Diseases—2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 21
Special Issue Editor
Interests: extracellular ATP; P2X7; inflammation; cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Extracellular ATP is now universally recognized as an ubiquitous extracellular messenger, with a key signaling role in virtually any disease. In this complex purinergic signaling network the P2X7 receptor has a special place. In fact, in the P2X family, P2X7 is no doubt the receptor that has shown the most stringent involvement in a large number of human pathologies, and has prompted the most intensive effort by Pharma Industry for the development of novel drugs. Ever since its cloning in 1996, over 4,200 Medline publications have appeared for a total number of over 10,000 citations. Despite increasing awareness of the role of P2X7 in human diseases, no P2X7-targeted drugs have so far been translated to the clinics, suggesting that a deeper understanding of the basic molecular and physiological properties of this receptor is needed, as well as a more thorough comprehension of the intracellular pathways affected by its activation or inhibition, respectively.
This Special Issue on “The Role of P2X7 Receptor in Human Health and Diseases” aims at providing an up-to-date appraisal of current knowledge on the participation of P2X7 to the pathogenesis of selected inflammatory, infectious, metabolic, neurodegenerative and neuromuscular diseases as well as cancer. Furthermore, a special emphasis will be placed on the increasingly important role that P2X7 plays in the modulation of the immune response and in supporting novel pathways for cell-to-cell communication such as for example the release of extracellular microvesicles. Finally, an update will also be provided on molecular and electrophysiological techniques and on animal models for the investigation of P2X7 structure and function.
Although this Special Issue will cover only a limited spectrum of the multiple pathophysiological settings of P2X7 activity, we hope that it will at least provide an agile summary of the current state of the art and inspiration for future investigation.
Prof. Dr. Francesco Di Virgilio
Guest Editor
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Keywords
- purinergic signalling
- extracellular ATP
- P2X7 receptor
- inflammation
- cancer
- diabetes
- neurodegeneration
- COVID
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