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Head and Neck Cancer: From Molecular Diagnosis to Targeted Therapy

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 513

Special Issue Editor


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Guest Editor
Department of Microscopic Morphology/Histology, Angiogenesis Research Center, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania
Interests: head and neck cancer; otorhinolaryngology; molecular diagnosis
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Special Issue Information

Dear Colleagues,

Head and neck squamous cell carcinoma (HNSCC) is a pressing concern due to its rising incidence in Europe and worldwide. HNSCCs are aggressive tumors often diagnosed at an advanced stage, posing significant challenges for effective treatment. The current therapeutic options are notably limited and fall short in providing comprehensive solutions.

In recent years, molecular approaches have shown promise for applications in diagnosing and providing implicit therapy for HNSCC. Notably, molecular methods have aimed to classify these tumors based on their anatomical locations, offering potential insights into tailoring treatment strategies.

We invite you, dear colleagues, to contribute to this Special Issue by submitting original research papers, insightful reviews, or concise communications focused on head and neck cancer pathology, diagnosis, and treatment. Manuscripts proposing novel, targeted therapeutic approaches grounded in molecular analyses will be the main focus of the Special Issue.

We firmly believe that, with your invaluable contributions, we can develop a molecular classification for head and neck tumors, a critical element currently absent in the field. Such a classification holds the promise of paving the way for personalized therapies. Furthermore, we hope to identify new molecular therapeutic targets that can be used to stratify these pathologically apparently remarkably uniform tumors.

This Special Issue is being coordinated by Prof. Dr. Marius L. Raica in conjunction with our Guest Editor's assistant Dr. Cristina-Stefania Dumitru [email protected] (Department of Microscopic Morphology/Histology, Angiogenesis Research Center, “Victor Babes” University of Medicine and Pharmacy, Sq. Eftimie Murgu no. 2, 300041 Timisoara, Timis, Romania).

Prof. Dr. Marius L. Raica
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • head and neck cancer
  • targeted therapy
  • tumor genetics
  • biomarkers
  • combination therapy
  • resistance to therapy

Published Papers (1 paper)

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Research

16 pages, 3629 KiB  
Article
NMR-Based Metabolomics of Blood Serum in Predicting Response to Induction Chemotherapy in Head and Neck Cancer—A Preliminary Approach
by Łukasz Boguszewicz, Agata Bieleń, Jarosław Dawid Jarczewski, Mateusz Ciszek, Agnieszka Skorupa, Jolanta Mrochem-Kwarciak, Krzysztof Składowski and Maria Sokół
Int. J. Mol. Sci. 2024, 25(14), 7555; https://doi.org/10.3390/ijms25147555 - 10 Jul 2024
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Abstract
The role of induction chemotherapy (iCHT) in locally advanced head and neck squamous cell carcinoma (LA-HNSCC) is still to be established due to high toxicity and variable response rates. The aim of this retrospective study is to use NMR-based serum metabolomics to predict [...] Read more.
The role of induction chemotherapy (iCHT) in locally advanced head and neck squamous cell carcinoma (LA-HNSCC) is still to be established due to high toxicity and variable response rates. The aim of this retrospective study is to use NMR-based serum metabolomics to predict the response rates to iCHT from the pretreatment samples. The studied group consisted of 46 LA-HNSCC patients treated with iCHT. The response to the treatment was evaluated by the clinical, fiberoptic, and radiological examinations made before and after iCHT. The proton nuclear magnetic resonance (1H NMR) serum spectra of the samples collected before iCHT were acquired with a 400 MHz spectrometer and were analyzed using multivariate and univariate statistical methods. A significant multivariate model was obtained only for the male patients. The treatment-responsive men with >75% primary tumor regression after iCHT showed pretreatment elevated levels of isoleucine, alanine, glycine, tyrosine, N-acetylcysteine, and the lipid compounds, as well as decreased levels of acetate, glutamate, formate, and ketone bodies compared to those who did not respond (regression of the primary tumor <75%). The results indicate that the nutritional status, capacity of the immune system, and the efficiency of metabolism related to protein synthesis may be prognostic factors for the response to induction chemotherapy in male HNSCC patients. However, larger studies are required that would validate the findings and could contribute to the development of more personalized treatment protocols for HNSCC patients. Full article
(This article belongs to the Special Issue Head and Neck Cancer: From Molecular Diagnosis to Targeted Therapy)
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