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Natural Products: New Insights into Overcoming Oxidative Stress in Pathological Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 20 February 2025 | Viewed by 2136

Special Issue Editor

Dr. Maria G. Bottone

E-Mail Website1 Website2 Website3
Guest Editor
Laboratory of Cellular Biology and Neurobiology, Department of Biology and Biotecnology, University of Pavia, 9-27100 Pavia, Italy
Interests: cell death; brain tumors; cisplatin; new platinum compounds; microscopy; immunohistochemistry; cell cultures
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The concept of oxidative stress as “a disturbance in the pro-oxidant–antioxidant balance in favor of the former” was introduced about 40 years ago, and, in the last ten years alone, about 200,000 articles studying the link between oxidative stress and the acute/chronic phase of several diseases (from metabolic and chronic disorders to cancers) have been published at PubMed.

The oxidative stress process is activated following an imbalance between the production of reactive oxygen species (ROS) and their accumulation in cells and tissues. Although ROS play a key role in both the maintenance of cellular homeostasis and the regulation of cell activity, they can significantly increase in the presence of specific environmental factors, e.g., pollutants, ionizing radiation, or antiblastic drugs.

ROS are mainly produced by the mitochondria, both in physiological and pathological conditions, but these organelles are unable to prevent ROS overproduction.

In the literature, it has been reported that oxidative stress can be responsible for the development of metabolic diseases, chronic/degenerative diseases, and tumors. Furthermore, it can be associated with the onset of autoimmune diseases, the acceleration of the organic aging process, and acute pathologies.

How can we avoid damage related to oxidative stress? Cells are able to produce a variety of antioxidant enzymes that may break down radical chain reactions. However, these ROS scavengers are not always sufficient to fight oxidative stress. A high level of antioxidants can be recovered through the diet, e.g., by the use of nutraceuticals. A regulated consumption of nutraceuticals can help in maintaining a stable redox state, preventing oxidative stress.

This Special Issue of International Journal of Molecular Sciences on “Natural Products: New Insights into Overcoming Oxidative Stress in Pathological Diseases”, supervised by Dr. Maria Grazia Bottone (University of Pavia, Italy) and supported by Dr. Fabrizio De Luca (University of Pavia, Italy). In this Special Issue, we invite you to contribute original research articles reporting data from both experimental and clinical studies, as well as review articles, that allow a better understanding of the effects of nutraceuticals, dietary supplements, and functional foods on different diseases showing the direct involvement of the oxidative stress pathway.

Dr. Maria G. Bottone
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • nutraceuticals
  • oxidative stress
  • antioxidants
  • ROS
  • redox signaling
  • oxidative stress
  • pathological diseases

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Published Papers (2 papers)

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Research

22 pages, 6451 KiB  
Article
Preliminary Studies about Valorization of Acmella oleracea Bioactive Content in Modern Dermato-Cosmetic Applications to Combat Skin Oxidative Stress
by Delia Turcov, Adriana Trifan, Adrian Catalin Puitel, Ramona Cimpoesu, Anca Zbranca-Toporas, Claudia Maxim, Daniela Suteu and Ana Simona Barna
Int. J. Mol. Sci. 2024, 25(16), 8886; https://doi.org/10.3390/ijms25168886 - 15 Aug 2024
Viewed by 561
Abstract
The development of products with skin-protective effects has been driven by the increasing incidence of skin diseases that are exacerbated by increasing pollution, urbanization, poor living, working, fatigue, dietary habits, and general treatment. The ability of antioxidants to protect the skin from oxidative [...] Read more.
The development of products with skin-protective effects has been driven by the increasing incidence of skin diseases that are exacerbated by increasing pollution, urbanization, poor living, working, fatigue, dietary habits, and general treatment. The ability of antioxidants to protect the skin from oxidative stress and its effects makes them one of the most important ingredients in today’s cosmetics. This article aims first to characterize the plant extracts obtained from Acmella oleracea (A. oleracea) and then to evaluate the preliminary criteria for a new marketed product: the stability, antioxidant activity, and in vitro behavior of certain serums based on A. oleracea plant extract and hyaluronic acid. The extracts were obtained by liquid–solid extraction methods (maceration (M), ultrasound-assisted extraction (UEA), and a combined method between these two (UEA + M) using an aqueous solution of ethyl alcohol as the extraction solvent. The determination of the amounts of compounds with antioxidant activity highlighted the fact that the extract obtained from the whole plant of A. oleracea using maceration in conditions of S/L = 1:30, 20 days, and an extraction solvent percentage of 50% led to obtaining the highest amount of polyphenols (30.42 μg GAE/g), while using the combined UAE + M method under conditions of S/L = 1:30, 6 min + 20 days, and 50% extraction solvent led to obtaining the highest amount of flavonoids (32.88 mg QE/g). The tests performed on dermato-cosmetic serums based on the plant extract and multimolecular hyaluronic acid (HA) (1 HA with HMW—1.0 mDa–1.6 mDa; HA with LMW—10 kDa–200 kDa; and HA OLIGO, MW < 10 kDa) led to the conclusion that they exhibit structural stability, good shear behavior revealing a satisfactory texture, and high physical stability during storage. These results encourage the transition to in-depth testing, both microbiological and dermatological, as a final step in the consideration of a new commercial product. Full article
(This article belongs to the Special Issue Natural Products: New Insights into Overcoming Oxidative Stress in Pathological Diseases)
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33 pages, 47187 KiB  
Article
A Phyto-mycotherapeutic Supplement, Namely Ganostile, as Effective Adjuvant in Brain Cancer Management: An In Vitro Study Using U251 Human Glioblastoma Cell Line
by Ludovica Gaiaschi, Fabrizio De Luca, Elisa Roda, Beatrice Ferrari, Claudio Casali, Chiara Rita Inguscio, Federica Gola, Enrico Pelloni, Elena Savino, Mauro Ravera, Paola Rossi and Maria Grazia Bottone
Int. J. Mol. Sci. 2024, 25(11), 6204; https://doi.org/10.3390/ijms25116204 - 5 Jun 2024
Viewed by 1161
Abstract
The current standard oncotherapy for glioblastoma is limited by several adverse side effects, leading to a short-term patient survival rate paralleled by a worsening quality of life (QoL). Recently, Complementary and Integrative Medicine’s (CIM) innovative approaches have shown positive impacts in terms of [...] Read more.
The current standard oncotherapy for glioblastoma is limited by several adverse side effects, leading to a short-term patient survival rate paralleled by a worsening quality of life (QoL). Recently, Complementary and Integrative Medicine’s (CIM) innovative approaches have shown positive impacts in terms of better response to treatment, side effect reduction, and QoL improvement. In particular, promising potential in cancer therapy has been found in compounds coming from phyto- and mycotherapy. The objective of this study was to demonstrate the beneficial effects of a new phyto-mycotherapy supplement, named Ganostile, in the human glioblastoma cell line U251, in combination with chemotherapeutic agents, i.e., Cisplatin and a new platinum-based prodrug. Choosing a supplement dosage that mimicked oral supplementation in humans (about 1 g/day), through in vitro assays, microscopy, and cytometric analysis, it has emerged that the cells, after 48hr continuous exposure to Ganostile in combination with the chemical compounds, showed a higher mortality and a lower proliferation rate than the samples subjected to the different treatments administered individually. In conclusion, our data support the use of Ganostile in integrative oncology protocols as a promising adjuvant able to amplify conventional and new drug effects and also reducing resistance mechanisms often observed in brain tumors. Full article
(This article belongs to the Special Issue Natural Products: New Insights into Overcoming Oxidative Stress in Pathological Diseases)
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