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Therapeutic Applications of Adipose-Derived Stem Cells in Disease and Health
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Therapeutic Applications of Adipose-Derived Stem Cells in Disease and Health

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 6792

Special Issue Editor

Dr. Byeong-Wook Song

E-Mail Website
Guest Editor
Department for Medical Science, College of Medicine, Catholic Kwandong University, Gangneung-si 25601, Gangwon-do, Republic of Korea
Interests: stem cells; exosome; cell therapy; proof-of-concept; tissue clearing; tissue-specific differentiation; degenerative disease; regenerative medicine

Special Issue Information

Dear Colleagues,

Adipose-derived Stem Cells (ASCs) are known to be have multipotency, immunosuppressive properties and low immunogenicity as a safe source of cell therapy. In addition to the treatment of un-manipulated ASCs, many studies have been conducted on functional enhancement and tissue-specific differentiation by regulation of extrinsic factors on the changes of stem cell biology. Studies on stem cell-free therapies by using cell-derived growth factors, exosomes, or cytokines have also been focused on the tissue regeneration by the topical enhancement at damaged region in many diseases. Despite of experimental evidences, this indicates that more accurate and rigorous research of ASCs are needed to make breakthrough toward therapeutic hurdles of the tissue regeneration in the field of basic, preclinical and clinical application.

This Special Issue aims at discussing the innovative strategies of ASC therapy from stem cell biology to clinical study for regenerative medicine. To expand the current knowledge and the application capacity of ASC therapy, experimental and and review articles are all welcome for consideration.

Dr. Byeong-Wook Song
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Adipose-derived stem cells
  • Exosomes
  • Cell-free therapy
  • Degenerative diseases
  • Tissue regeneration
  • Paracrine effect
  • Differentiation
  • Stem cell tracking
  • Stem cell niches
  • Animal model
  • Clinical trials

Published Papers (2 papers)

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Research

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20 pages, 6769 KiB  
Article
Suppressing Pyroptosis Augments Post-Transplant Survival of Stem Cells and Cardiac Function Following Ischemic Injury
by Chang Youn Lee, Seahyoung Lee, Seongtae Jeong, Jiyun Lee, Hyang-Hee Seo, Sunhye Shin, Jun-Hee Park, Byeong-Wook Song, Il-Kwon Kim, Jung-Won Choi, Sang Woo Kim, Gyoonhee Han, Soyeon Lim and Ki-Chul Hwang
Int. J. Mol. Sci. 2021, 22(15), 7946; https://doi.org/10.3390/ijms22157946 - 26 Jul 2021
Cited by 3 | Viewed by 2718
Abstract
The acute demise of stem cells following transplantation significantly compromises the efficacy of stem cell-based cell therapeutics for infarcted hearts. As the stem cells transplanted into the damaged heart are readily exposed to the hostile environment, it can be assumed that the acute [...] Read more.
The acute demise of stem cells following transplantation significantly compromises the efficacy of stem cell-based cell therapeutics for infarcted hearts. As the stem cells transplanted into the damaged heart are readily exposed to the hostile environment, it can be assumed that the acute death of the transplanted stem cells is also inflicted by the same environmental cues that caused massive death of the host cardiac cells. Pyroptosis, a highly inflammatory form of programmed cell death, has been added to the list of important cell death mechanisms in the damaged heart. However, unlike the well-established cell death mechanisms such as necrosis or apoptosis, the exact role and significance of pyroptosis in the acute death of transplanted stem cells have not been explored in depth. In the present study, we found that M1 macrophages mediate the pyroptosis in the ischemia/reperfusion (I/R) injured hearts and identified miRNA-762 as an important regulator of interleukin 1β production and subsequent pyroptosis. Delivery of exogenous miRNA-762 prior to transplantation significantly increased the post-transplant survival of stem cells and also significantly ameliorated cardiac fibrosis and heart functions following I/R injury. Our data strongly suggest that suppressing pyroptosis can be an effective adjuvant strategy to enhance the efficacy of stem cell-based therapeutics for diseased hearts. Full article
(This article belongs to the Special Issue Therapeutic Applications of Adipose-Derived Stem Cells in Disease and Health)
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Review

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27 pages, 844 KiB  
Review
ADSC-Based Cell Therapies for Musculoskeletal Disorders: A Review of Recent Clinical Trials
by Seahyoung Lee, Dong-Sik Chae, Byeong-Wook Song, Soyeon Lim, Sang Woo Kim, Il-Kwon Kim and Ki-Chul Hwang
Int. J. Mol. Sci. 2021, 22(19), 10586; https://doi.org/10.3390/ijms221910586 - 30 Sep 2021
Cited by 14 | Viewed by 3462
Abstract
Recently published clinical trials involving the use of adipose-derived stem cells (ADSCs) indicated that approximately one-third of the studies were conducted on musculoskeletal disorders (MSD). MSD refers to a wide range of degenerative conditions of joints, bones, and muscles, and these conditions are [...] Read more.
Recently published clinical trials involving the use of adipose-derived stem cells (ADSCs) indicated that approximately one-third of the studies were conducted on musculoskeletal disorders (MSD). MSD refers to a wide range of degenerative conditions of joints, bones, and muscles, and these conditions are the most common causes of chronic disability worldwide, being a major burden to the society. Conventional treatment modalities for MSD are not sufficient to correct the underlying structural abnormalities. Hence, ADSC-based cell therapies are being tested as a form of alternative, yet more effective, therapies in the management of MSDs. Therefore, in this review, MSDs subjected to the ADSC-based therapy were further categorized as arthritis, craniomaxillofacial defects, tendon/ligament related disorders, and spine disorders, and their brief characterization as well as the corresponding conventional therapeutic approaches with possible mechanisms with which ADSCs produce regenerative effects in disease-specific microenvironments were discussed to provide an overview of under which circumstances and on what bases the ADSC-based cell therapy was implemented. Providing an overview of the current status of ADSC-based cell therapy on MSDs can help to develop better and optimized strategies of ADSC-based therapeutics for MSDs as well as help to find novel clinical applications of ADSCs in the near future. Full article
(This article belongs to the Special Issue Therapeutic Applications of Adipose-Derived Stem Cells in Disease and Health)
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