Is There An Aging Signature Across Human Tissues?
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (15 February 2021) | Viewed by 16767
Special Issue Editor
Special Issue Information
Dear Colleagues,
Aging is the major risk factor for chronic diseases and an inevitable process in humans. The global population of individuals over the age of 65 is growing and most older individuals are affected by multiple chronic conditions or multimorbidity that lead to an increased risk of mortality. Understanding how and why we age, that is, the underlying biological mechanisms of aging, become important to develop interventions aimed at delaying or preventing the onset of chronic conditions and other age-related diseases. High-throughput methods for examining changes in transcriptome, metabolome, proteome, methylome, etc will allow us to elucidate some of the changes that occur with age in several human tissues and to analyse if these molecular signatures correlate with chronological age and/or physiological age. If there is any an aging signature across tissues still remains unknown. In this Special Issue titled, “Is There An Aging Signature Across Human Tissues?” we would like to highlight the latest advances in this research topic. We invite authors to submit original research and review articles revealing the molecular mechanisms and/or molecular signature of biological aging across tissues, including, but not limited to, the following topics:
- Mitochondrial dysfunction in skeletal muscle and brain
- Cellular Senescence in peripheral blood mononuclear cells
- Oxidative Stress
- Autophagy mechanisms in aging and disease
- Chronic Inflammation and age-related diseases
- Biological Aging
- Chronological Aging
- DNA methylation in skeletal muscle
- Protein synthesis
Dr. Marta Gonzalez-Freire
Guest Editor
Manuscript Submission Information
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