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Behavioral Neuroscience: From Genes to Brain Mechanisms Underlying Behaviour in Normal and Pathological Conditions

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 3381

Special Issue Editors


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Guest Editor
Department of Biomedical Science, Università Degli Studi di Padova, Padua, Italy
Interests: brain circuits; neurobiology; neuroscience; zebrafish

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Guest Editor
Department of General Psychology, Università Degli Studi di Padova, Padua, Italy
Interests: neurobiology; neuroscience; model organisms

Special Issue Information

Dear Colleagues,

Brain disorders are among the major causes of disability worldwide and their incidence is projected to increase in the next decades. Their etiology and pathophysiology remain largely elusive due to the complex interplay of genetic and environmental factors involved. The need for ongoing research to gain a greater understanding of the processes underlying brain mechanisms and its disorders has never been more important. Changes in behaviors occurring in the vast majority of people with brain disorders, are commonly used as diagnostic tool and at the same time may open a window into their neural bases. In this context, model organisms in combination with powerful genetic strategies play a central role in the investigation of the biological mechanisms and processes that are involved in brain disorders and behavioral dysfunctions.

This Special Issue aims to promote a multi-level approach to uncover the neural mechanisms underlying animal and human behavior related to brain disorders. As such, this Special Issue welcomes submissions of original research and review articles related to any aspect of the brain–behavior relation and its disorders: from molecular biology and genetics, to biochemical, neurochemical, neurophysiological, neuroendocrine, pharmacological, neurocomputation and neuroimaging studies.

Dr. Marco Dal Maschio
Prof. Dr. Maria Elena Miletto Petrazzini
Guest Editors

Manuscript Submission Information

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Keywords

  • animal models
  • brain mechanisms
  • brain disorders
  • behavior
  • genes

Published Papers (2 papers)

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Research

18 pages, 2636 KiB  
Article
Relationship between GABA-Ergic System and the Expression of Mephedrone-Induced Reward in Rats—Behavioral, Chromatographic and In Vivo Imaging Study
by Olga Wronikowska-Denysiuk, Agnieszka Michalak, Anna Pankowska, Łukasz Kurach, Paulina Kozioł, Artur Łazorczyk, Katarzyna Kochalska, Katarzyna Targowska-Duda, Anna Boguszewska-Czubara and Barbara Budzyńska
Int. J. Mol. Sci. 2023, 24(12), 9958; https://doi.org/10.3390/ijms24129958 - 9 Jun 2023
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Abstract
Mephedrone is a psychoactive drug that increases dopamine, serotonin and noradrenaline levels in the central nervous system via interaction with transporters or monoamines. The aim of the presented study was to assess the role of the GABA-ergic system in the expression of mephedrone-induced [...] Read more.
Mephedrone is a psychoactive drug that increases dopamine, serotonin and noradrenaline levels in the central nervous system via interaction with transporters or monoamines. The aim of the presented study was to assess the role of the GABA-ergic system in the expression of mephedrone-induced reward. For this purpose, we conducted (a) a behavioral evaluation of the impact of baclofen (a GABAB receptors agonist) and GS39783 (a positive allosteric modulator of GABAB receptors) on the expression of mephedrone-induced conditioned place preference (CPP) in rats, (b) an ex vivo chromatographic determination of the GABA level in the hippocampi of rats subchronically treated with mephedrone and (c) an in vivo evaluation of GABA hippocampal concentration in rats subchronically administered with mephedrone using magnetic resonance spectroscopy (MRS). The results show that GS39783 (but not baclofen) blocked the expression of CPP induced by (20 mg/kg of) mephedrone. The behavioral effect was consistent with chromatographic analysis, which showed that mephedrone (5 and 20 mg/kg) led to a decrease in GABA hippocampal concentration. Altogether, the presented study provides a new insight into the involvement of the GABA-ergic system in the rewarding effects of mephedrone, implying that those effects are at least partially mediated through GABAB receptors, which suggests their potential role as new targets for the pharmacological management of mephedrone use disorder. Full article
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15 pages, 5531 KiB  
Article
Ablation of the Presynaptic Protein Mover Impairs Learning Performance and Decreases Anxiety Behavior in Mice
by Eva Maria Schleicher, Thomas A. Bayer, Trendelina Iseni, Frederik Wilhelm Ott, Jannek Moritz Wagner, Julio S. Viotti, Thomas Dresbach and Yvonne Bouter
Int. J. Mol. Sci. 2022, 23(19), 11159; https://doi.org/10.3390/ijms231911159 - 22 Sep 2022
Cited by 1 | Viewed by 1603
Abstract
The presynaptic protein Mover/TPRGL/SVAP30 is absent in Drosophila and C. elegans and differentially expressed in synapses in the rodent brain, suggesting that it confers specific functions to subtypes of presynaptic terminals. In order to investigate how the absence of this protein affects behavior [...] Read more.
The presynaptic protein Mover/TPRGL/SVAP30 is absent in Drosophila and C. elegans and differentially expressed in synapses in the rodent brain, suggesting that it confers specific functions to subtypes of presynaptic terminals. In order to investigate how the absence of this protein affects behavior and learning, Mover knockout mice (KO) were subjected to a series of established learning tests. To determine possible behavioral and cognitive alterations, male and female 8-week-old KO and C57Bl/6J wildtype (WT) control mice were tested in a battery of memory and anxiety tests. Testing included the cross maze, novel object recognition test (NOR), the Morris water maze (MWM), the elevated plus maze (EPM), and the open field test (OF). Mover KO mice showed impaired recognition memory in the NOR test, and decreased anxiety behavior in the OF and the EPM. Mover KO did not lead to changes in working memory in the cross maze or spatial reference memory in the MWM. However, a detailed analysis of the swimming strategies demonstrated allocentric-specific memory deficits in male KO mice. Our data indicate that Mover appears to control synaptic properties associated with specific forms of memory formation and behavior, suggesting that it has a modulatory role in synaptic transmission. Full article
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