International Journal of Molecular Sciences

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Dear Colleagues,

In the last few decades, dental tissue engineering has become one of the most studied fields in dentistry, showing promising results for bone tissue regeneration in experimental and clinical models. Even if a bone demonstrates self-remodeling properties, in some cases, due to anomalies, injuries or pathologies like peri-implantitis or periodontitis, bone regeneration may be required. This Special Issue, “Molecular Research on Biomaterials for Bone Tissue Engineering and Periodontal Disease”, of the International Journal of Molecular Sciences will comprise a selection of research papers and reviews, focused on the molecular level, contributing to the evaluation of the aptitude of dental biomaterials used for tissue regeneration after soft and hard tissue resorption with an emphsis on those used in periodontics. Additionally, in vitro and in vivo studies on the molecular mechanisms involved in tissue regeneration are of interest, since they will provide an important contribution to the development of regeneration strategies and to the identification of key biological regulation processes that still remain uncovered in dentistry.

Dr. Bruna Sinjari
Guest Editor

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Keywords

dentistry
regenerative medicine
tissue regeneration
periodontal disease
biomaterials
bone regeneration

Published Papers (1 paper)

Research

20 pages, 1709 KiB

Open AccessArticle

An In Vitro Study on the Application of Silver-Doped Platelet-Rich Plasma in the Prevention of Post-Implant-Associated Infections

by Chiara Ceresa, Fabio Travagin, Alice Marchetti, Francesco Tessarolo, Letizia Fracchia, Giovanni Battista Giovenzana and Michela Bosetti

Int. J. Mol. Sci. 2024, 25(9), 4842; https://doi.org/10.3390/ijms25094842 - 29 Apr 2024

Viewed by 367

Abstract

Implant therapy is a common treatment option in dentistry and orthopedics, but its application is often associated with an increased risk of microbial contamination of the implant surfaces that cause bone tissue impairment. This study aims to develop two silver-enriched platelet-rich plasma (PRP) multifunctional scaffolds active at the same time in preventing implant-associated infections and stimulating bone regeneration. Commercial silver lactate (L) and newly synthesized silver deoxycholate:β-Cyclodextrin (B), were studied in vitro. Initially, the antimicrobial activity of the two silver soluble forms and the PRP enriched with the two silver forms has been studied on microbial planktonic cells. At the same time, the biocompatibility of silver-enriched PRPs has been assessed by an MTT test on human primary osteoblasts (hOBs). Afterwards, an investigation was conducted to evaluate the activity of selected concentrations and forms of silver-enriched PRPs in inhibiting microbial biofilm formation and stimulating hOB differentiation. PRP-L (0.3 µg/mm²) and PRP-B (0.2 µg/mm²) counteract Staphylococcus aureus, Staphylococcus epidermidis and Candida albicans planktonic cell growth and biofilm formation, preserving hOB viability without interfering with their differentiation capability. Overall, the results obtained suggest that L- and B-enriched PRPs represent a promising preventive strategy against biofilm-related implant infections and demonstrate a new silver formulation that, together with increasing fibrin binding protecting silver in truncated cone-shaped cyclic oligosaccharides, achieved comparable inhibitory results on prokaryotic cells at a lower concentration. Full article

(This article belongs to the Special Issue Molecular Research on Biomaterials for Bone Tissue Engineering and Periodontal Disease)

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