Signaling Pathways in Mammary Gland Homeostasis and Breast Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 2408
Special Issue Editor
Interests: breast cancer; signaling pathways; mammary gland homeostasis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
During the female reproductive lifetime, the breast mammary epithelium responds to the changes that are induced cyclically by the female sex hormones, estrogen and progesterone. The physiological changes induced by these hormones are mediated by signaling pathways that result in expansion and remodeling of the gland if pregnancy does not occur. Therefore, positive and negative mechanisms must exist within the epithelium to regulate these dynamic changes to maintain homeostasis and prevent hyperproliferation and transformation. In breast cancer, these signaling pathways are rewired and regulatory mechanisms are lost, which results in tumorigenesis. This issue will focus on signaling pathways that regulate mammary epithelium homeostasis and how disruption of these pathways can result in breast cancer. Original research articles and full length review articles are welcome.
Dr. Deborah A. Lannigan
Guest Editor
Manuscript Submission Information
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Keywords
- breast cancer
- signaling pathways
- mammary epithelium homeostasis
