Brugada Syndrome: Causes, Diagnosis, and Treatment-2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 5821
Special Issue Editors
Interests: electrophysiology; catheter ablation of cardiac arrhythmias; ablation of atrial fibrillation; nonfluoroscopic mapping; cardiac pacing; biventricular pacing; nonexcitatory cardiac contractility modulation
Special Issues, Collections and Topics in MDPI journals
Interests: Brugada syndrome; sudden cardiac death; ventricular arrhythmias; cardiac cellular physiology; genetic testing
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Brugada syndrome (BrS) is characterized by a coved elevation of the ST-segment (type 1 BrS pattern) on the electrocardiogram, which may occur spontaneously or after a drug challenge. This syndrome is associated with an increased risk of sudden cardiac death (SCD) due to ventricular arrhythmias caused by an arrhythmogenic substrate. Diagnosis of BrS is challenging, since the first clinical manifestation of the syndrome may be SCD (or aborted SCD), which often occurs in early adulthood during sleep. Variants in the SCN5A gene seem to account for less than one-third of clinically-confirmed cases, while the genetics of the remaining cases remain unknown, or disputed, at best. Identifying asymptomatic individuals at risk of SCD is imperative. However, as current genetic testing is limited in the majority of cases, alternative tests must be developed to identify these individuals. This Special Issue will feature a selection of original research, review articles, and commentaries related to the current understanding of molecular genetics and cellular physiology, as well as diastolic and therapeutic options, in BrS.
Prof. Carlo Pappone
Dr. Michelle Monasky
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Brugada syndrome
- Sudden cardiac death
- Genetic testing
- Arrhythmia
- Ventricular arrhythmias
- SCN5A
- Channelopathy
- Variant
- Mutation
- Segregation analysis
- Functional studies
- Calcium channel
- Potassium channel
- Polymorphism
- Syncope
- Mortality
- Arrhythmogenic substrate
- Ablation
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.