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Role of MicroRNAs in Health and Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 20 April 2026 | Viewed by 800

Special Issue Editor


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Guest Editor
Department of Biomedical Sciences, University of Sassari, Sassari, Italy
Interests: trace elements; cadmium; toxicity; neurodegenerative disorders; cancer stem cells; oncology; miRNA
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Special Issue Information

Dear Colleagues,

MicroRNAs (miRNAs) are endogenous, short, noncoding RNA sequences of 18–25 nucleotides that regulate the expression of genes at the post-transcriptional level in a sequence-specific manner. Due to their high stability and the ability to detect them in human body fluids, miRNAs are being studied as a new class of biomarkers. Numerous studies have demonstrated their utility in biomedical research, particularly in cancer.

This Special Issue will focus on recent studies on microRNAs and their application in cancer research. The effect of miRNAs depends on their specific targets, and they can therefore exert tumor-promoting (oncomiRs) or tumor-suppressing functions. The early diagnosis of cancer is crucial to improving therapeutic outcomes and patient survival.  miRNAs could serve as excellent diagnostic candidates due to their remarkable stability in body fluids and their significant biological roles. In addition, their involvement in circulation, shielded from endogenous RNase activity, makes them particularly suitable for use as biomarkers in non-invasive diagnostic applications.

We welcome researchers to submit original research papers, reviews, and short communications.

Dr. Roberto Madeddu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • miRNA
  • cancer
  • biomarkers
  • function
  • miRNA target

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Published Papers (1 paper)

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Review

18 pages, 2278 KB  
Review
MicroRNAs in Tissue Regeneration: Lessons from Animal Models
by Sarah E. Walker, Alicia Piazza, Robert L. Carlone and Gaynor E. Spencer
Int. J. Mol. Sci. 2025, 26(20), 10043; https://doi.org/10.3390/ijms262010043 - 15 Oct 2025
Viewed by 428
Abstract
MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression. Over the past two decades, multiple studies have established the importance of miRNAs in regulating a variety of biological processes, one of which includes regenerative repair. Although many miRNAs have [...] Read more.
MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression. Over the past two decades, multiple studies have established the importance of miRNAs in regulating a variety of biological processes, one of which includes regenerative repair. Although many miRNAs have been shown to regulate the expression of genes that are required for regeneration, few studies have extrapolated these findings from cell culture to in vivo animal models or reported comparative work between regenerating and non-regenerating systems. Here, we review the most current literature highlighting the role of distinct miRNAs in regulating the repair of different tissues, focusing on the heart, limb and spinal cord. In exploring existing work, we emphasize the importance of using animal models to provide foundational knowledge that could potentially lead to future therapeutic strategies to allow for functional regenerative repair in humans. Full article
(This article belongs to the Special Issue Role of MicroRNAs in Health and Diseases)
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