Advanced Synthetic Methodologies in Drug Development
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: 29 July 2024 | Viewed by 1873
Special Issue Editor
Special Issue Information
Dear Colleagues,
Drugs are defined as chemical entities endowed with biological properties used for medicinal purposes. They interact with complex chemical systems in an extremely specific way in order to avoid side effects. The presence of specific groups in obtaining potent and selective molecules requires the development of advanced synthetic methodologies such as such as organo-catalyzed, photo-catalyzed, stereo-controlled and solvent-free reactions.
I present this Special Issue as a collection of novel trends in medicinal chemistry, organic synthesis and the characterization of small molecules, using novel methodologies chemical technologies, such as flow chemistry, electrochemistry and bio-catalysis. Particular attention will be paid to the development and application of green synthetic techniques. Moreover, in silico studies, rational design, structural optimization of hits and leads and their application with tentative or established targets are welcome. In conclusion, this Special Issue focuses on all aspects of synthetic methodologies ranging from the design and synthesis of these active compounds to their pharmacological evaluation, computational modeling and structural biology studies that pursue to understand the interactions between the molecule and the biological target. Papers that focus on innovative aspects or novel biological mechanisms of action or novel target validation are also welcome.
Full papers, communications and reviews are welcome in this Special Issue.
Dr. Davide Moi
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- organic chemistry
- medicinal chemistry
- catalysis
- photo-catalysis
- green chemistry
- drug design
- drug analysis
- flow chemistry
