Updates of Calcineurin/NFAT Signaling in Human Health and Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (26 May 2022) | Viewed by 14361
Special Issue Editor
Special Issue Information
Dear Colleagues,
The intracelluar signaling cascade regulated by a phosphatase, calcineurin, and its substrate transcription factor, nuclear factor of activated T cells (NFAT), has been demonstrated to play a crucial role not only in the development, differentiation, and function of immune, cardiovascular, nervous, bone, urinary, and genital organs but also in inducing various diseases, including cancer, in those organs. The versatile function of this cascade is achieved by forming a molecular family consisting of multipe genes and splicing variants with extensive diversity in expressing organs, target genes and proteins, and effects. Since the discovery of calcineurin inhibitors, cyclosporin and tacrolimus, as immunosuppressants for preventing graft-versus-host disease and graft rejection in the 1980s, their application has been expanded for treating various immune-related diseases. Their usages are frequently accompanied by broad and/or serious side effects, though new medicines superior to cyclosporin or tacrolimus have not been generated for almost 40 years. To break through this situation, this Special Issue will focus on, but not be limited to, recent advances across physiological and pathophysiological functions, underlying molecular mechanisms, and attempts to generate new regulators of calcineurin/NFAT signaling. Based on the prospective contribution of authors at the forefront of calcineurin/NFAT study, I would be happy if this issue could help to create new means of overcoming veteran immunosuppressants.
Dr. Osamu Kaminuma
Guest Editor
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Keywords
- allergy
- bone metabolism
- calcineurin
- cancer
- cell cycle
- immunosuppressant
- osmolarity
- reproduction
- NFAT
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