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The Role of Calcium Conducting and Calcium Regulated Channels in Human Health and Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 3166

Special Issue Editors


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Guest Editor
Laboratory of Biophysics, Faculty of Natural Science and Technology, Saarland University, 66123 Saarbrücken, Germany
Interests: calcium signaling; fluorescence imaging; membrane biophysics; ion transport across biological membranes

E-Mail Website
Guest Editor
Theoretical Medicine and Biosciences, Saarland University, Saarbruecken, Germany
Interests: red blood cells; ion channels; calcium signaling; microscopy; hematology
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Special Issue Information

Dear Colleagues,

Calcium and its molecular signaling in cells and cell organelles are vital processes throughout the life cycle of the majority of cells. This includes the regulation of ion channels by calcium and the regulation of calcium by ion channels. The scope of this Special Issue, titled "The Role of Calcium Conducting and Calcium Regulated Channels in Human Health and Disease", to be published in the International Journal of Molecular Science, is to integrate research on channel-mediated calcium signaling in both excitable and non-excitable cells, under physiological and pathophysiological conditions. This refers to calcium channels, non-selective cation channels and calcium-activated ion channels, and includes investigations based on molecular biology, patch-clamp and all other functional evidence for ion channel activity. The ion channels can be characterized in vivo, in isolated primary cells or tissues, and in model cells, but also in cell-free systems, such as black lipid membranes. This Special Issue considers original research, new methodological approaches, and short or comprehensive reviews.

Prof. Dr. Ingolf Bernhardt
Prof. Dr. Lars Kaestner
Guest Editors

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Keywords

  • calcium channels
  • non-selective cation channels
  • calcium-activated channels
  • patch-clamp
  • calcium-induced calcium release
  • channelopathies

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Published Papers (1 paper)

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Research

21 pages, 5693 KiB  
Article
Impact of the Voltage-Gated Calcium Channel Antagonist Nimodipine on the Development of Oligodendrocyte Precursor Cells
by Michael Enders, Alicia Weier, Rittika Chunder, Young An, Franziska Bremm, Andreas Feigenspan, Christian Buettner, Arif Bülent Ekici, Enrico Mingardo, Benjamin Odermatt and Stefanie Kuerten
Int. J. Mol. Sci. 2023, 24(4), 3716; https://doi.org/10.3390/ijms24043716 - 13 Feb 2023
Cited by 1 | Viewed by 2668
Abstract
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). While most of the current treatment strategies focus on immune cell regulation, except for the drug siponimod, there is no therapeutic intervention that primarily aims at neuroprotection and remyelination. [...] Read more.
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). While most of the current treatment strategies focus on immune cell regulation, except for the drug siponimod, there is no therapeutic intervention that primarily aims at neuroprotection and remyelination. Recently, nimodipine showed a beneficial and remyelinating effect in experimental autoimmune encephalomyelitis (EAE), a mouse model of MS. Nimodipine also positively affected astrocytes, neurons, and mature oligodendrocytes. Here we investigated the effects of nimodipine, an L-type voltage-gated calcium channel antagonist, on the expression profile of myelin genes and proteins in the oligodendrocyte precursor cell (OPC) line Oli-Neu and in primary OPCs. Our data indicate that nimodipine does not have any effect on myelin-related gene and protein expression. Furthermore, nimodipine treatment did not result in any morphological changes in these cells. However, RNA sequencing and bioinformatic analyses identified potential micro (mi)RNA that could support myelination after nimodipine treatment compared to a dimethyl sulfoxide (DMSO) control. Additionally, we treated zebrafish with nimodipine and observed a significant increase in the number of mature oligodendrocytes (* p 0.05). Taken together, nimodipine seems to have different positive effects on OPCs and mature oligodendrocytes. Full article
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