Interplay between Epigenetics and Metabolism in Cancer and Other Disorders
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (28 February 2021) | Viewed by 10665
Special Issue Editor
Special Issue Information
Dear Colleagues,
This Special Issue of International Journal of Molecular Sciences focuses on the interplay between epigenetics and metabolism in physiological and pathological conditions.
Numerous studies have indicated that cellular metabolism and epigenetics are highly interconnected, contributing not only to physiological changes but also to numerous differnt human disorders and cancers. The epigenetic regulation of genes mediated by DNA- and histone-modifying enzymes (DNMT, HAT, HDAC, KAT, KDM, BET, etc.) is influenced by oncogene-mediated metabolic alterations. Such metabolic changes affect the presence or accesibility of cofactors that are required for the catalytic activity of epigenetic modifying enzymes. In addition, these metabolic alterations may produce oncometabolites that abnormally activate or inhibit such modifying enzymes, altering the epigenome. And, vice versa, epigenetic deregulation impacts metabolic gene expression in cancers, resulting in metabolomic alterations. As a result, the interplay between metabolism and epigenetics is crucial for the development of human diseases and tumorigenesis. Discovering novel molecular mechanisms linking the two pathways and targeting their downstream substrates could provide novel therapeutic targets to treat patients with different diseases.
In this issue, we are particularly interested in the regulation and mechanism of epigenetic enzymes and metabolic enzymes in cancer.
We warmly welcome submissions, including original research manuscripts and comprehensive reviews, on this exciting topic.
Dr. So Hee Kwon
Guest Editor
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Keywords
- cancer epigenetics
- cancer metabolism
- DNMT
- TET
- HAT
- HDAC
- KMT
- KDM
- metabolic enzymes
- metabolic stress
- oncometabolites
- epigenetic enzyme inhibitors
- cancer metabolism inhibitors
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