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Heart and Cancer Interactions: Cardiovascular Toxicities and Beyond

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 5667

Special Issue Editors


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Guest Editor
Department of Precision Medicine, University of Campania "L. Vanvitelli", 80138 Naples, Italy
Interests: Medical Oncology

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Guest Editor
Department of Translational Medical Sciences, Federico II University, Via Pansini 5, Edificio 2, 80131 Naples, NA, Italy
Interests: Immuno-oncology
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Guest Editor
Department of Translational Medical Sciences, Federico II University, Naples, Italy
Interests: heart failure; echocardiography; right ventricular function; pulmonary vascular disease; pulmonary arterial hypertension; cardio-oncology
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Chief Guest Editor
Università degli Studi di Napoli Federico II, Naples, Italy
Interests: Cardio- oncology; heart failure.

Special Issue Information

Dear Colleagues,

In the last few decades, along with an increase in longevity, a progressive spread in the prevalence of both cancer and cardiovascular diseases has been observed, especially in the elderly. Both these conditions, together with well-known and potential cardiovascular side effects of different chemotherapeutic regimens, have a negative impact on patients’ quality of life and adversely affect prognosis. Besides chemotherapy-induced cardiotoxicity, there are several other possible interactions between cardiovascular and neoplastic diseases that still need to be elucidated, with modulation of the immune system playing an important role in these conditions. For instance, patients newly diagnosed with cancer may have a pre-existing cardiac disease, and this condition may be challenging and raise issues concerning oncological treatment management. Furthermore, cancer and heart failure share common risk factors that, at least in part, can explain the close association between these conditions.

Therefore, for this special issue of IJMS, we invite authors to contribute original research articles that expand the growing efforts to understand the interactions between oncological and cardiovascular diseases, as well as review articles that describe the current state of the art on these topics. We are particularly interested in articles describing the impact of antineoplastic treatments on the heart, on the cardiovascular system and on the immune modulation, and the molecular and pathophysiological mechanisms that cancer and heart disease may share.

Dr. Carlo G. Tocchetti
Dr. Maria Rosaria Galdiero
Dr. Valentina Mercurio
Dr. Teresa Troiani
Guest Editors

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Keywords

  • cancer
  • heart
  • cardiotoxicity
  • immunology

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Published Papers (1 paper)

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Review

18 pages, 15677 KiB  
Review
RAAS: A Convergent Player in Ischemic Heart Failure and Cancer
by Texali C. Garcia-Garduño, Jorge R. Padilla-Gutierrez, Diego Cambrón-Mora and Yeminia Valle
Int. J. Mol. Sci. 2021, 22(13), 7106; https://doi.org/10.3390/ijms22137106 - 1 Jul 2021
Cited by 11 | Viewed by 5181
Abstract
The current global prevalence of heart failure is estimated at 64.34 million cases, and it is expected to increase in the coming years, especially in countries with a medium-low sociodemographic index where the prevalence of risk factors is increasing alarmingly. Heart failure is [...] Read more.
The current global prevalence of heart failure is estimated at 64.34 million cases, and it is expected to increase in the coming years, especially in countries with a medium-low sociodemographic index where the prevalence of risk factors is increasing alarmingly. Heart failure is associated with many comorbidities and among them, cancer has stood out as a contributor of death in these patients. This connection points out new challenges both in the context of the pathophysiological mechanisms involved, as well as in the quality of life of affected individuals. A hallmark of heart failure is chronic activation of the renin-angiotensin-aldosterone system, especially marked by a systemic increase in levels of angiotensin-II, a peptide with pleiotropic activities. Drugs that target the renin-angiotensin-aldosterone system have shown promising results both in the prevention of secondary cardiovascular events in myocardial infarction and heart failure, including a lower risk of certain cancers in these patients, as well as in current cancer therapies; therefore, understanding the mechanisms involved in this complex relationship will provide tools for a better diagnosis and treatment and to improve the prognosis and quality of life of people suffering from these two deadly diseases. Full article
(This article belongs to the Special Issue Heart and Cancer Interactions: Cardiovascular Toxicities and Beyond)
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