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Advances and Perspectives in Nucleic Acid Memory

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (20 April 2024) | Viewed by 727

Special Issue Editor


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Guest Editor
Department of Nanoengineering, The Joint School of Nanoscience and Nanoengineering, North Carolina A&T State University, Greensboro, NC 27401, USA
Interests: DNA memory; DNA digital data storage; nucleic acid memory; information storage; DNA nanotechnology; molecular information
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Special Issue Information

Dear Colleagues,

Current data storage materials and techniques are approaching their economic and physical limits. At the same time, the demand for memory is increasing exponentially. By the middle of this century, the world will experience catastrophic shortages of digital memory. Therefore, the memory industry has realized a critical need to explore alternative storage materials. DNA is a promising alternative to digital data storage materials when information density, durability, and operation energy become critical. The National Science Foundation states, "Currently, semiconductor-based information technologies are facing many challenges as Complementary Metal-Oxide- Semiconductor (CMOS)/Moore's Law approaches its physical limits, with no obvious replacement technologies in sight." Further, the NSF has indicated that "such a research effort can have a significant impact on the future of information storage and retrieval technologies," and "the integration of these two fields [Semiconductors and Synthetic Biology] is likely to lead to a new technological boom for information processing and storage." Additionally, Semiconductors Synthetic Biology (SemiSynBio) consortium representatives participated in the White House Bioeconomy Summit on October 7, 2019 to inform legislators of the importance of this emerging trend. The trend is evident from multi agencies' recent and continuous funding; the increasing number of publications; the establishment of the SemiSynBio Consortium and the produced roadmap; the establishment of the DNA Data Storage Alliance, which includes industry and academic institutions; and the increasing number of patents and inventions. The current Special Issue focuses on the topic of nucleic acids-based memory and aims to motivate more scientific activities on this emerging topic. 

Dr. Reza Zadegan
Guest Editor

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Keywords

  • DNA memory
  • DNA digital data storage
  • nucleic acid memory
  • information storage
  • DNA nanotechnology
  • molecular information

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Published Papers (1 paper)

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Review

17 pages, 1409 KiB  
Review
Toward DNA-Based Recording of Biological Processes
by Hyeri Jang and Sung Sun Yim
Int. J. Mol. Sci. 2024, 25(17), 9233; https://doi.org/10.3390/ijms25179233 - 26 Aug 2024
Viewed by 376
Abstract
Exploiting the inherent compatibility of DNA-based data storage with living cells, various cellular recording approaches have been developed for recording and retrieving biologically relevant signals in otherwise inaccessible locations, such as inside the body. This review provides an overview of the current state [...] Read more.
Exploiting the inherent compatibility of DNA-based data storage with living cells, various cellular recording approaches have been developed for recording and retrieving biologically relevant signals in otherwise inaccessible locations, such as inside the body. This review provides an overview of the current state of engineered cellular memory systems, highlighting their design principles, advantages, and limitations. We examine various technologies, including CRISPR-Cas systems, recombinases, retrons, and DNA methylation, that enable these recording systems. Additionally, we discuss potential strategies for improving recording accuracy, scalability, and durability to address current limitations in the field. This emerging modality of biological measurement will be key to gaining novel insights into diverse biological processes and fostering the development of various biotechnological applications, from environmental sensing to disease monitoring and beyond. Full article
(This article belongs to the Special Issue Advances and Perspectives in Nucleic Acid Memory)
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