Molecular Research on Cancer Stem Cells
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 20 November 2024 | Viewed by 83
Special Issue Editor
Interests: cancer stem cells; glioblastoma; asymmetric division; HMGA proteins; diet; gene expression
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Following the groundbreaking studies published by Bonnet and Dick, who identified cancer stem cells (CSCs) as a CD34+/CD38− subpopulation of leukemic cells capable of initiating tumors upon injection into nude mice, a plethora of studies have deeply explored the mysteries of these seemingly unstoppable cells, both in hematologic malignancies and solid tumors.
These studies have revealed not only the unique features of CSCs, such as their ability to initiate and sustain the tumor, to adapt their phenotype overtime (plasticity), to resist a broad range of drugs, and to generate a diversified subset of CSCs (heterogeneity), but also their invaluable translational potential. Nevertheless, several questions, concerning their metabolism, metastatic potential, interaction with the microenvironment, crosstalk with the immune system, and more, persist unanswered.
This Special Issue aims to collect original articles, reviews, and perspectives addressing the latest findings in this hot scientific field, including, but not limited to, CSC metabolism, CSC niches, mechanisms of CSC dormancy and re-activation, CSC–microenvironment interactions, immune system evasion, circulating CSCs, microbiome–CSC relationship, effective targeting of CSCs, etc.
Dr. Sabrina Battista
Guest Editor
Manuscript Submission Information
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Keywords
- self-renewal
- microenvironment
- plasticity
- epigenetics
- epithelial-mesenchymal transition
- heterogeneity
- targeting
- dormancy
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